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Gene Review:

seqA - negative modulator of initiation of...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0675, JW0674, hsm-1

Sikora, A.E. et al., Herrick, J. et al., Brézellec, P. et al.

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Disease relevance of seqA

Interestingly, seqA is only present in a few DamMT-specifying proteobacteria [1].

High impact information on seqA

A mutant of the hobH gene reveals partial asynchronous initiation of DNA replication [2].
The effects of ectopic expression of dnaA were specific as analogous expression of another gene coding for a replication regulator, seqA, had no significant changes in growth and DNA synthesis in the cgtA mutant [3].

References

DomainSieve: a protein domain-based screen that led to the identification of dam-associated genes with potential link to DNA maintenance. Brézellec, P., Hoebeke, M., Hiet, M.S., Pasek, S., Ferat, J.L. Bioinformatics (2006) [Pubmed]
Parental strand recognition of the DNA replication origin by the outer membrane in Escherichia coli. Herrick, J., Kern, R., Guha, S., Landoulsi, A., Fayet, O., Malki, A., Kohiyama, M. EMBO J. (1994) [Pubmed]
DNA replication defect in the Escherichia coli cgtA(ts) mutant arising from reduced DnaA levels. Sikora, A.E., Zielke, R., Wegrzyn, A., Wegrzyn, G. Arch. Microbiol. (2006) [Pubmed]

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