Disease relevance of nagA

• Repression and induction of the nag regulon of Escherichia coli K-12: the roles of nagC and nagA in maintenance of the uninduced state [1].

High impact information on nagA

• Three open reading frames, which are subsequently referred to as nagA, nagC and nagD, were detected in this sequence [2].
• Genetic complementation and enzyme assays have shown that the first of these, nagA, encodes N-acetyl glucosamine-6-phosphate deacetylase [2].
• The defect in curli production in nagA or nagC mutants was alleviated by deletion of the GlcNAc transporter gene, nagE [3].
• Growth of a wild-type strain on media containing additional GlcNAc reduced curli gene transcription to a level similar to the level observed when nagA was deleted [3].
• The products of these nag genes were identified by complementation of E. coli strains with mutations in nagA, nagB, and nagE [4].

Biological context of nagA

• The nag genes appear to be organized in an operon: nagD nagC nagA nagB nagE [4].

Other interactions of nagA

• The chromosomal nagA gene of A. nidulans was disrupted by replacement with the argB marker gene [5].

References