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Gene Review

nagA  -  N-acetylglucosamine-6-phosphate deacetylase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0665, JW0663
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Disease relevance of nagA

  • Repression and induction of the nag regulon of Escherichia coli K-12: the roles of nagC and nagA in maintenance of the uninduced state [1].

High impact information on nagA

  • Three open reading frames, which are subsequently referred to as nagA, nagC and nagD, were detected in this sequence [2].
  • Genetic complementation and enzyme assays have shown that the first of these, nagA, encodes N-acetyl glucosamine-6-phosphate deacetylase [2].
  • The defect in curli production in nagA or nagC mutants was alleviated by deletion of the GlcNAc transporter gene, nagE [3].
  • Growth of a wild-type strain on media containing additional GlcNAc reduced curli gene transcription to a level similar to the level observed when nagA was deleted [3].
  • The products of these nag genes were identified by complementation of E. coli strains with mutations in nagA, nagB, and nagE [4].

Biological context of nagA


Other interactions of nagA

  • The chromosomal nagA gene of A. nidulans was disrupted by replacement with the argB marker gene [5].


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