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Gene Review

argB  -  acetylglutamate kinase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3950, JW5553
 
 
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Disease relevance of argB

 

High impact information on argB

  • A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis: acetylglutamate synthase activity requires complex formation with acetylglutamate kinase [3].
  • ARG5,6 encodes a precursor that is maturated in the mitochondria into acetylglutamate kinase and acetylglutamyl-phosphate reductase, catalyzing the second and third steps in the pathway [3].
  • A. nidulans strains carrying recombinant plasmids integrated as single copies at the chromosomal argB locus were identified [4].
  • The chromosomal nagA gene of A. nidulans was disrupted by replacement with the argB marker gene [5].
  • We have shown that the Aspergillus nidulans ans1 sequence enhances the efficiency of transformation when introduced into vectors containing argB or trpC genes [6].
 

Associations of argB with chemical compounds

References

  1. Nucleotide sequence of Escherichia coli argB and argC genes: comparison of N-acetylglutamate kinase and N-acetylglutamate-gamma-semialdehyde dehydrogenase with homologous and analogous enzymes. Parsot, C., Boyen, A., Cohen, G.N., Glansdorff, N. Gene (1988) [Pubmed]
  2. Arginine biosynthesis in Thermotoga maritima: characterization of the arginine-sensitive N-acetyl-L-glutamate kinase. Fernández-Murga, M.L., Gil-Ortiz, F., Llácer, J.L., Rubio, V. J. Bacteriol. (2004) [Pubmed]
  3. A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis: acetylglutamate synthase activity requires complex formation with acetylglutamate kinase. Abadjieva, A., Pauwels, K., Hilven, P., Crabeel, M. J. Biol. Chem. (2001) [Pubmed]
  4. Analysis of the regulation of the Aspergillus nidulans penicillin biosynthesis gene aat (penDE), which encodes acyl coenzyme A:6-aminopenicillanic acid acyltransferase. Litzka, O., Bergh, K.T., Brakhage, A.A. Mol. Gen. Genet. (1995) [Pubmed]
  5. Cloning and characterization of the nagA gene that encodes beta-n-acetylglucosaminidase from Aspergillus nidulans and its expression in Aspergillus oryzae. Kim, S., Matsuo, I., Ajisaka, K., Nakajima, H., Kitamoto, K. Biosci. Biotechnol. Biochem. (2002) [Pubmed]
  6. Enhancement of Aspergillus nidulans transformation by the ans1 sequence. Dzikowska, A., Wegleński, P. Acta Microbiol. Pol. (1989) [Pubmed]
  7. Structure of acetylglutamate kinase, a key enzyme for arginine biosynthesis and a prototype for the amino acid kinase enzyme family, during catalysis. Ramón-Maiques, S., Marina, A., Gil-Ortiz, F., Fita, I., Rubio, V. Structure (Camb.) (2002) [Pubmed]
 
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