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Gene Review:

dadA - D-amino acid dehydrogenase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1177, JW1178, dadR

Wild, J. et al., Wild, J. et al., Janes, B.K. et al.

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Disease relevance of dadA

All 70 Escherichia coli K12 dadA mutants isolated either by this method or by other selection procedures map at a locus which is near to hemA and closely linked with dadR [1].

High impact information on dadA

The clone complemented the alanine defects of dadA strains [2].
The first type consisted in changes in the dadR regulatory site of the dad operon increasing the synthesis of D-amino acid dehydrogenase [3].

References

D-Amino acid dehydrogenase of Escherichia coli K12: positive selection of mutants defective in enzyme activity and localization of the structural gene. Wild, J., Klopotowski, T. Mol. Gen. Genet. (1981) [Pubmed]
Alanine catabolism in Klebsiella aerogenes: molecular characterization of the dadAB operon and its regulation by the nitrogen assimilation control protein. Janes, B.K., Bender, R.A. J. Bacteriol. (1998) [Pubmed]
Two distinct types of mutations conferring to Escherichia coli K12 capability of D-tryptophan utilization. Wild, J., Zakrzewska, B., Walczak, W., Kłopotowski, T. Acta Microbiol. Pol. (1987) [Pubmed]

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