Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ldcA - murein tetrapeptide carboxypeptidase; LD...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1180, JW1181, ycgQ

Templin, M.F. et al., Baum, E.Z. et al.

Baum, Crespo-Carbone, Foleno, Peng, Hilliard, Abbanat, Goldschmidt, Bush,

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Disease relevance of ldcA

The enzyme L,D-carboxypeptidase A is involved in the recycling of bacterial peptidoglycan and is essential in Escherichia coli during stationary phase [1].

High impact information on ldcA

The gene named ldcA encodes a cytoplasmic L, D-carboxypeptidase, which releases the terminal D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine containing turnover products of the cell wall polymer murein [2].

References

Identification of a dithiazoline inhibitor of Escherichia coli L,D-carboxypeptidase A. Baum, E.Z., Crespo-Carbone, S.M., Foleno, B., Peng, S., Hilliard, J.J., Abbanat, D., Goldschmidt, R., Bush, K. Antimicrob. Agents Chemother. (2005) [Pubmed]
A defect in cell wall recycling triggers autolysis during the stationary growth phase of Escherichia coli. Templin, M.F., Ursinus, A., Höltje, J.V. EMBO J. (1999) [Pubmed]

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