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Gene Review

ldcA  -  murein tetrapeptide carboxypeptidase; LD...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1180, JW1181, ycgQ
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Disease relevance of ldcA


High impact information on ldcA

  • The gene named ldcA encodes a cytoplasmic L, D-carboxypeptidase, which releases the terminal D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine containing turnover products of the cell wall polymer murein [2].


  1. Identification of a dithiazoline inhibitor of Escherichia coli L,D-carboxypeptidase A. Baum, E.Z., Crespo-Carbone, S.M., Foleno, B., Peng, S., Hilliard, J.J., Abbanat, D., Goldschmidt, R., Bush, K. Antimicrob. Agents Chemother. (2005) [Pubmed]
  2. A defect in cell wall recycling triggers autolysis during the stationary growth phase of Escherichia coli. Templin, M.F., Ursinus, A., Höltje, J.V. EMBO J. (1999) [Pubmed]
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