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Gene Review:

cobS - cobalamin synthase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1987, JW1970

Lawrence, J.G. et al., Maggio-Hall, L.A. et al.

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Disease relevance of cobS

The cob operon of E. coli comprises the cobU gene, encoding the bifunctional cobinamide kinase-guanylyltransferase; the cobS gene, encoding cobalamin synthetase; and the cobT gene, encoding dimethylbenzimidazole phosphoribosyltransferase [1].
In Salmonella enterica, the last step of the synthesis of adenosylcobamide is catalysed by the cobalamin synthase enzyme encoded by the cobS gene of this bacterium [2].

High impact information on cobS

The physiological roles of these sequences were verified by the isolation of Tn10 insertion mutations in the cobS and cobT genes [1].

References

The cobalamin (coenzyme B12) biosynthetic genes of Escherichia coli. Lawrence, J.G., Roth, J.R. J. Bacteriol. (1995) [Pubmed]
The last step in coenzyme B(12) synthesis is localized to the cell membrane in bacteria and archaea. Maggio-Hall, L.A., Claas, K.R., Escalante-Semerena, J.C. Microbiology (Reading, Engl.) (2004) [Pubmed]

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