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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

wcaN  -  putative regulatory subunit for GalU

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2036, JW2027, galF
 
 
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Disease relevance of galF

  • We report the functional characterization of the galF gene of strain VW187 (Escherichia coli O7:K1), which encodes a polypeptide displaying structural features common to bacterial UDP-glucose pyrophosphorylases, including the E. coli GalU protein [1].
 

High impact information on galF

  • However, the Rcs system can potentially influence levels of capsular polysaccharide production by increasing galF transcription and influencing the available pool of biosynthetic precursors [2].
 

Associations of galF with chemical compounds

  • Furthermore, using a pair of galF-/galU+ and galF/galU+ isogenic strains, we demonstrated that the presence of GalF is associated with an increased concentration of intracellular UDP-glucose as well as with an enhancement of the thermal stability of the UDP-glucose pyrophosphorylase in vivo [1].

References

  1. The GalF protein of Escherichia coli is not a UDP-glucose pyrophosphorylase but interacts with the GalU protein possibly to regulate cellular levels of UDP-glucose. Marolda, C.L., Valvano, M.A. Mol. Microbiol. (1996) [Pubmed]
  2. Transcriptional organization and regulation of the Escherichia coli K30 group 1 capsule biosynthesis (cps) gene cluster. Rahn, A., Whitfield, C. Mol. Microbiol. (2003) [Pubmed]
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