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Gene Review

EIF4E2  -  eukaryotic translation initiation factor...

Homo sapiens

Synonyms: 4E-LP, 4EHP, EIF4EL3, Eukaryotic translation initiation factor 4E homologous protein, Eukaryotic translation initiation factor 4E type 2, ...
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High impact information on EIF4E2

  • Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein [1].
  • The putative promoter of EIF4E2 contained no TATA box but did contain a transcription initiator region (Inr) and numerous other sequence motifs characteristic of regulated promoters [2].
  • One of the genes (EIF4E1) contained six introns, but the other gene (EIF4E2) was intronless, flanked by Alu sequences and 14-base pair (bp) direct repeats, and terminated by a short poly(A) stretch, all characteristics of retrotransposons [2].
  • EIF4E2 contained only two of the three polyadenylation signals present in EIF4E1 [2].

Biological context of EIF4E2

  • Numerous additional intronless eIF4E pseudogenes were found, but unlike EIF4E2, all contained premature in-frame stop codons [2].

Other interactions of EIF4E2

  • We report that 4EHP is modified by ISG15 and ISGylated 4EHP has a much higher cap structure-binding activity [3].


  1. Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein. Rom, E., Kim, H.C., Gingras, A.C., Marcotrigiano, J., Favre, D., Olsen, H., Burley, S.K., Sonenberg, N. J. Biol. Chem. (1998) [Pubmed]
  2. Cloning and characterization of human eIF4E genes. Gao, M., Rychlik, W., Rhoads, R.E. J. Biol. Chem. (1998) [Pubmed]
  3. ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP. Okumura, F., Zou, W., Zhang, D.E. Genes Dev. (2007) [Pubmed]
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