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Gene Review: 

hypA  -  protein involved in nickel insertion into...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2721, JW2696
 
 
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Disease relevance of hypA

  • Six genes, arranged as a single operon, were identified, and designated hypA, B, F, C, D and E based on the sequence similarities of all of them, except hypF, to genes from the hydrogenase pleiotropic operon (hyp) from Escherichia coli [1].
 

High impact information on hypA

  • To examine the functions of these proteins in nickel insertion, the hybF gene, which is a homolog of hypA essential for maturation of hydrogenases 1 and 2 from Escherichia coli, was overexpressed, and the product was purified [2].
 

Analytical, diagnostic and therapeutic context of hypA

  • The hypA gene encoding the chsp10 of C. trachomatis serovar E/Bour was cloned into the pQE-60 vector (QIAGEN, Inc.) following PCR amplification from genomic DNA [3].

References

  1. Molecular analysis of a microaerobically induced operon required for hydrogenase synthesis in Rhizobium leguminosarum biovar viciae. Rey, L., Murillo, J., Hernando, Y., Hidalgo, E., Cabrera, E., Imperial, J., Ruiz-Argüeso, T. Mol. Microbiol. (1993) [Pubmed]
  2. HybF, a zinc-containing protein involved in NiFe hydrogenase maturation. Blokesch, M., Rohrmoser, M., Rode, S., Böck, A. J. Bacteriol. (2004) [Pubmed]
  3. Use of monoclonal antibodies to facilitate identification, cloning, and purification of Chlamydia trachomatis hsp10. LaVerda, D., Byrne, G.I. J. Clin. Microbiol. (1997) [Pubmed]
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