Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

kduD - 2-dehydro-3-deoxy-D-gluconate 5...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2840, JW2810, ygeC, yqeD

Condemine, G. et al., Nasser, W. et al.

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High impact information on kduD

The functions of two of these genes are known: kduD codes for the 2-keto-3-deoxygluconate oxydoreductase and kdul for the 5-keto-4-deoxyuronate isomerase, two enzymes of the pectin degradation pathway. kdgC has 36% homology with pectate lyase genes of the periplasmic family but its product does not seem to have pectinolytic activity [1].
Despite the presence of potential KdgR binding sites (KdgR-box) in the regulatory regions of four genes involved in pectin catabolism (kdgC, kduD, pem, kdgA) and in a pectinase secretion gene outC, no DNA-repressor complex could be observed by in vitro experiments [2].

References

Analysis of an Erwinia chrysanthemi gene cluster involved in pectin degradation. Condemine, G., Robert-Baudouy, J. Mol. Microbiol. (1991) [Pubmed]
Specific interactions of Erwinia chrysanthemi KdgR repressor with different operators of genes involved in pectinolysis. Nasser, W., Reverchon, S., Condemine, G., Robert-Baudouy, J. J. Mol. Biol. (1994) [Pubmed]

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