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Gene Review: 

agaA  -  pseudo

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3123, JW5527, yraA
 
 
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Disease relevance of agaA

  • In some strains of E. coli, particularly the common K-12 strain, a portion of this cluster is missing because of a site-specific recombination event that occurred between sites in agaW and agaA [1].
  • An agarase gene (agaA) was cloned from genomic DNA of Vibrio sp. strain JT0107 [2].
  • To produce heterologous alpha-galactosidase in T. thermophilus, the isogenes agaA and agaB of Bacillus stearothermophilus KVE36 were cloned into an Escherichia coli-Thermus shuttle vector [3].

References

  1. Application of AgaR repressor and dominant repressor variants for verification of a gene cluster involved in N-acetylgalactosamine metabolism in Escherichia coli K-12. Ray, W.K., Larson, T.J. Mol. Microbiol. (2004) [Pubmed]
  2. Cloning and sequencing of agaA, a unique agarase 0107 gene from a marine bacterium, Vibrio sp. strain JT0107. Sugano, Y., Matsumoto, T., Kodama, H., Noma, M. Appl. Environ. Microbiol. (1993) [Pubmed]
  3. Production of recombinant alpha-galactosidases in Thermus thermophilus. Fridjonsson, O., Mattes, R. Appl. Environ. Microbiol. (2001) [Pubmed]
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