Disease relevance of degQ

• Characterization of degQ and degS, Escherichia coli genes encoding homologs of the DegP protease [1].

High impact information on degQ

• The latter phenotype is rescued by a plasmid expressing the degS gene but not by plasmids expressing the degQ or degP genes [1].
• Deletions in the degQ gene cause no obvious growth defect, while those in the degS gene result in a small-colony phenotype [1].
• A plasmid expressing degQ rescues the temperature-sensitive phenotype of a strain bearing the degP41 deletion, implying that DegQ, like DegP, functions as a periplasmic protease in vivo [1].

Chemical compound and disease context of degQ

• The structural features of the PPA2-coding locus are similar to those of the loci in E. coli for the degQ and degS serine protease genes [2].

References