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Gene Review:

npr - phosphohistidinoprotein-hexose...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3195, JW3173, ptsO, rpoR, yhbK

Chang, S.C. et al., Serkina, A.V. et al., Powell, B.S. et al.

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Disease relevance of npr

The cloned npr gene of Streptomyces cacaoi encodes a 60-kDa protein (prepro-Npr) consisting of a typical secretory signal peptide, a propeptide (22 kDa), and the 35-kDa mature metalloprotease (Npr) [1].
A metalloprotease gene of Brevibacillus brevis (npr) was expressed in Escherichia coli in a soluble form as native Npr precursor [2].

High impact information on npr

We designate these proteins IIANtr (ptsN) and NPr (npr) [3].

References

The roles of propeptide in maturation and secretion of Npr protease from Streptomyces. Chang, S.C., Chang, P.C., Lee, Y.H. J. Biol. Chem. (1994) [Pubmed]
Propeptide of the metalloprotease of Brevibacillus brevis 7882 is a strong inhibitor of the mature enzyme. Serkina, A.V., Gorozhankina, T.F., Shevelev, A.B., Chestukhina, G.G. FEBS Lett. (1999) [Pubmed]
Novel proteins of the phosphotransferase system encoded within the rpoN operon of Escherichia coli. Enzyme IIANtr affects growth on organic nitrogen and the conditional lethality of an erats mutant. Powell, B.S., Court, D.L., Inada, T., Nakamura, Y., Michotey, V., Cui, X., Reizer, A., Saier, M.H., Reizer, J. J. Biol. Chem. (1995) [Pubmed]

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