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Gene Review

ptsN  -  sugar-specific enzyme IIA component of PTS

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3193, JW3171, rpoP, yhbI
 
 
 
 
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High impact information on ptsN

  • One truncates rpoN while the second disrupts another gene (ptsN) in the rpoN operon and does not affect classical nitrogen regulation [1].
  • We designate these proteins IIANtr (ptsN) and NPr (npr) [1].
  • Plasmid clones of ptsN prevent suppression by either disruption mutation indicating that this gene is important for lethality caused by erats. rpoN and six neighboring genes were sequenced and compared with sequences in the database [1].
  • Several sugars and tricarboxylic acid cycle intermediates inhibited growth of the ptsN disruption mutant on medium containing an amino acid or nucleoside base as a combined source of nitrogen, carbon, and energy [1].

References

  1. Novel proteins of the phosphotransferase system encoded within the rpoN operon of Escherichia coli. Enzyme IIANtr affects growth on organic nitrogen and the conditional lethality of an erats mutant. Powell, B.S., Court, D.L., Inada, T., Nakamura, Y., Michotey, V., Cui, X., Reizer, A., Saier, M.H., Reizer, J. J. Biol. Chem. (1995) [Pubmed]
 
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