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Gene Review:

ggt - gamma-glutamyltranspeptidase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3431, JW3412

Suzuki, H. et al., Suzuki, H. et al., Chevalier, C. et al.

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Disease relevance of ggt

DNA sequence of the Escherichia coli K-12 gamma-glutamyltranspeptidase gene, ggt [1].

High impact information on ggt

The H. pylori ggt gene consists of a 1681 basepair (bp) open reading frame encoding a protein with a signal sequence and a calculated molecular mass of 61 kDa [2].
The DNA sequence of ggt, the gene that codes for gamma-glutamyltranspeptidase (EC 2.3.2.2) of Escherichia coli K-12, has been determined [1].
Based on the results of mapping of ggt, eight strains were selected from a gene library of E. coli [3].
The ggt was subcloned to the BamHI site of pUC18 and the recombinant plasmid pSH101 was obtained [3].

References

DNA sequence of the Escherichia coli K-12 gamma-glutamyltranspeptidase gene, ggt. Suzuki, H., Kumagai, H., Echigo, T., Tochikura, T. J. Bacteriol. (1989) [Pubmed]
Essential role of Helicobacter pylori gamma-glutamyltranspeptidase for the colonization of the gastric mucosa of mice. Chevalier, C., Thiberge, J.M., Ferrero, R.L., Labigne, A. Mol. Microbiol. (1999) [Pubmed]
Molecular cloning of Escherichia coli K-12 ggt and rapid isolation of gamma-glutamyltranspeptidase. Suzuki, H., Kumagai, H., Echigo, T., Tochikura, T. Biochem. Biophys. Res. Commun. (1988) [Pubmed]

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