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Gene Review

uspB  -  universal stress (ethanol tolerance)...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3479, JW3461, yhiO
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Disease relevance of uspB


High impact information on uspB

  • In contrast to uspA, stationary-phase induction of uspB requires the sigma factor sigmaS [1].
  • Overexpression of UspB causes cell death in stationary phase, whereas mutants of uspB are sensitive to exposure to ethanol but not heat in stationary phase [1].
  • In contrast, we report here that stationary phase induction of sigma(S)-dependent genes, uspB and cfa, is attenuated and that sigma(S) accumulates at a lower rate in ftsK1 cells [2].

Other interactions of uspB


  1. uspB, a new sigmaS-regulated gene in Escherichia coli which is required for stationary-phase resistance to ethanol. Farewell, A., Kvint, K., Nyström, T. J. Bacteriol. (1998) [Pubmed]
  2. The Escherichia coli ftsK1 mutation attenuates the induction of sigma(S)-dependent genes upon transition to stationary phase. Diez, A.A., Tunlid, A., Nyström, T. FEMS Microbiol. Lett. (2002) [Pubmed]
  3. Evaluation of inducible promoters on the secretion of a ZZ-proinsulin fusion protein in Escherichia coli. Mergulhão, F.J., Monteiro, G.A., Larsson, G., Bostrom, M., Farewell, A., Nyström, T., Cabral, J.M., Taipa, M.A. Biotechnol. Appl. Biochem. (2003) [Pubmed]
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