Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

uspB - universal stress (ethanol tolerance)...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3479, JW3461, yhiO

Farewell, A. et al., Diez, A.A. et al., Mergulhão, F.J. et al.

Farewell, Kvint, Nyström,

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Disease relevance of uspB

uspB, a new sigmaS-regulated gene in Escherichia coli which is required for stationary-phase resistance to ethanol [1].

High impact information on uspB

In contrast to uspA, stationary-phase induction of uspB requires the sigma factor sigmaS [1].
Overexpression of UspB causes cell death in stationary phase, whereas mutants of uspB are sensitive to exposure to ethanol but not heat in stationary phase [1].
In contrast, we report here that stationary phase induction of sigma(S)-dependent genes, uspB and cfa, is attenuated and that sigma(S) accumulates at a lower rate in ftsK1 cells [2].

Other interactions of uspB

Four inducible promoters, uspA, uspB, lacUV5 and malK, were evaluated in the expression of the fusion protein ZZ-proinsulin by Escherichia coli [3].

References

uspB, a new sigmaS-regulated gene in Escherichia coli which is required for stationary-phase resistance to ethanol. Farewell, A., Kvint, K., Nyström, T. J. Bacteriol. (1998) [Pubmed]
The Escherichia coli ftsK1 mutation attenuates the induction of sigma(S)-dependent genes upon transition to stationary phase. Diez, A.A., Tunlid, A., Nyström, T. FEMS Microbiol. Lett. (2002) [Pubmed]
Evaluation of inducible promoters on the secretion of a ZZ-proinsulin fusion protein in Escherichia coli. Mergulhão, F.J., Monteiro, G.A., Larsson, G., Bostrom, M., Farewell, A., Nyström, T., Cabral, J.M., Taipa, M.A. Biotechnol. Appl. Biochem. (2003) [Pubmed]

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