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Gene Review

prlC  -  oligopeptidase A

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3483, JW3465, opdA
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Disease relevance of prlC


High impact information on prlC

  • A plasmid carrying an amber mutation in prlC [prlC31(AM)] was unable to complement except in an amber suppressor background [2].
  • The nucleotide sequence of the prlC1 suppressor allele was determined and predicts an in-frame duplication of seven amino acids, providing further confirmation that the prlC suppressor phenotype results from changes in the endopeptidase OpdA [2].


  1. Location of the prlC (opdA) gene on the physical map of Escherichia coli. Conlin, C.A., Miller, C.G. J. Bacteriol. (1993) [Pubmed]
  2. Escherichia coli prlC encodes an endopeptidase and is homologous to the Salmonella typhimurium opdA gene. Conlin, C.A., Trun, N.J., Silhavy, T.J., Miller, C.G. J. Bacteriol. (1992) [Pubmed]
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