Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

gabT - 4-aminobutyrate aminotransferase, PLP...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2656, JW2637

Bartsch, K. et al., Park, J. et al.

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Disease relevance of gabT

Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD) [1].

High impact information on gabT

4-Aminobutyrate aminotransferase, which catalyzes the conversion of 4-aminobutyrate to succinic semialdehyde, is a key enzyme of the 4-aminobutyrate shunt [2].
The isolated precursor of 4-aminobutyrate aminotransferase contains pyridoxal 5-phosphate and exhibits catalytic activity (18 units/mg) comparable to that of the mature enzyme (20 units/mg) [2].
The nucleotide sequence of gabT, coding for glutamate:succinic semialdehyde transaminase (EC 2.6.1.19), alternatively known as 4-aminobutyrate transaminase, was determined [1].

Associations of gabT with chemical compounds

The gabD gene, encoding succinic semialdehyde dehydrogenase (EC 1.2.1.16), was cloned and shown to be located adjacent to the 5' end of gabT [1].

References

Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD). Bartsch, K., von Johnn-Marteville, A., Schulz, A. J. Bacteriol. (1990) [Pubmed]
Isolation and characterization of recombinant mitochondrial 4-aminobutyrate aminotransferase. Park, J., Osei, Y.D., Churchich, J.E. J. Biol. Chem. (1993) [Pubmed]

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