Chemical Compound Review:
pyridoxal 3-hydroxy-5-(hydroxymethyl)- 2-methyl...
Synonyms:
CHEMBL102970, AIDS-006783, CHEBI:17310, HMDB01545, ANW-64418, ...
- Hormonal induction of tyrosine aminotransferase activity in host liver and hepatoma no. 7777 of normal and cofactor-depleted animals. Tryfiates, G.P., Saus, F.L., Morris, H.P. J. Natl. Cancer Inst. (1975)
- Alkaline phosphatase: placental and tissue-nonspecific isoenzymes hydrolyze phosphoethanolamine, inorganic pyrophosphate, and pyridoxal 5'-phosphate. Substrate accumulation in carriers of hypophosphatasia corrects during pregnancy. Whyte, M.P., Landt, M., Ryan, L.M., Mulivor, R.A., Henthorn, P.S., Fedde, K.N., Mahuren, J.D., Coburn, S.P. J. Clin. Invest. (1995)
- Pyridoxal phosphate as an antisickling agent in vitro. Kark, J.A., Tarassoff, P.G., Bongiovanni, R. J. Clin. Invest. (1983)
- Abnormal regulation of plasma pyridoxal 5'-phosphate in patients with liver disease. Mitchell, D., Wagner, C., Stone, W.J., Wilkinson, G.R., Schenker, S. Gastroenterology (1976)
- Relationship between pyridoxal 5'-phosphate deficiency and aminotransferase levels in alcoholic hepatitis. Diehl, A.M., Potter, J., Boitnott, J., Van Duyn, M.A., Herlong, H.F., Mezey, E. Gastroenterology (1984)
- Vitamin B6 metabolism in chronic alcohol abuse The effect of ethanol oxidation on hepatic pyridoxal 5'-phosphate metabolism. Vech, R.L., Lumeng, L., Li, T.K. J. Clin. Invest. (1975)
- Plasma pyridoxal phosphate in anxiety disorders. Emmanuel, N.P., Lydiard, R.B., Reynolds, R.D., Roberts, J., Johnson, M., Mintzer, O., Ballenger, J.C. Biol. Psychiatry (1994)
- Nutrient-dense foods and exercise in frail elderly: effects on B vitamins, homocysteine, methylmalonic acid, and neuropsychological functioning. de Jong, N., Chin A Paw, M.J., de Groot, L.C., Rutten, R.A., Swinkels, D.W., Kok, F.J., van Staveren, W.A. Am. J. Clin. Nutr. (2001)
- Phenelzine treatment of panic disorder: lack of effect on pyridoxal phosphate levels. Lydiard, R.B., Laraia, M.T., Howell, E.F., Fossey, M.D., Reynolds, R.D., Ballenger, J.C. Journal of clinical psychopharmacology. (1989)
- Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6. Waymire, K.G., Mahuren, J.D., Jaje, J.M., Guilarte, T.R., Coburn, S.P., MacGregor, G.R. Nat. Genet. (1995)
- X-linked pyridoxine-responsive sideroblastic anemia due to a Thr388-to-Ser substitution in erythroid 5-aminolevulinate synthase. Cox, T.C., Bottomley, S.S., Wiley, J.S., Bawden, M.J., Matthews, C.S., May, B.K. N. Engl. J. Med. (1994)
- Mutations in antiquitin in individuals with pyridoxine-dependent seizures. Mills, P.B., Struys, E., Jakobs, C., Plecko, B., Baxter, P., Baumgartner, M., Willemsen, M.A., Omran, H., Tacke, U., Uhlenberg, B., Weschke, B., Clayton, P.T. Nat. Med. (2006)
- Vitamin B6-responsive and -unresponsive cystathioninuria: two variant molecular forms. Pascal, T.A., Gaull, G.E., Beratis, N.G., Gillam, B.M., Tallan, H.H., Hirschhorn, K. Science (1975)
- Pharmacology of cloned P2X receptors. North, R.A., Surprenant, A. Annu. Rev. Pharmacol. Toxicol. (2000)
- Evolution of biosynthetic pathways: a common ancestor for threonine synthase, threonine dehydratase and D-serine dehydratase. Parsot, C. EMBO J. (1986)
- Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. Robinson, K., Mayer, E.L., Miller, D.P., Green, R., van Lente, F., Gupta, A., Kottke-Marchant, K., Savon, S.R., Selhub, J., Nissen, S.E. Circulation (1995)
- Vitamin B6 metabolism in liver and liver-derived tumors. Meisler, N.T., Nutter, L.M., Thanassi, J.W. Cancer Res. (1982)
- Role of lysine 39 of alanine racemase from Bacillus stearothermophilus that binds pyridoxal 5'-phosphate. Chemical rescue studies of Lys39 --> Ala mutant. Watanabe, A., Kurokawa, Y., Yoshimura, T., Kurihara, T., Soda, K., Esaki, N., Watababe, A. J. Biol. Chem. (1999)
- Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. Graham, I.M., Daly, L.E., Refsum, H.M., Robinson, K., Brattström, L.E., Ueland, P.M., Palma-Reis, R.J., Boers, G.H., Sheahan, R.G., Israelsson, B., Uiterwaal, C.S., Meleady, R., McMaster, D., Verhoef, P., Witteman, J., Rubba, P., Bellet, H., Wautrecht, J.C., de Valk, H.W., Sales Lúis, A.C., Parrot-Rouland, F.M., Tan, K.S., Higgins, I., Garcon, D., Andria, G. JAMA (1997)
- Intestinal hydrolysis of pyridoxal 5'-phosphate in vitro and in vivo in the rat. Effect of protein binding and pH. Middleton, H.M. Gastroenterology (1986)
- X-ray structure of MalY from Escherichia coli: a pyridoxal 5'-phosphate-dependent enzyme acting as a modulator in mal gene expression. Clausen, T., Schlegel, A., Peist, R., Schneider, E., Steegborn, C., Chang, Y.S., Haase, A., Bourenkov, G.P., Bartunik, H.D., Boos, W. EMBO J. (2000)
- delta-Aminolevulinic acid synthetase in erythroblasts of patients with pyridoxine-responsive anemia. Hypercatabolism caused by the increased susceptibility to the controlling protease. Aoki, Y., Muranaka, S., Nakabayashi, K., Ueda, Y. J. Clin. Invest. (1979)
- Anion channel blockers inhibit lysosomal enzyme secretion from human neutrophils without affecting generation of superoxide anion. Korchak, H.M., Eisenstat, B.A., Hoffstein, S.T., Dunham, P.B., Weissmann, G. Proc. Natl. Acad. Sci. U.S.A. (1980)
- Gyrate atrophy of the choroid and retina with hyperornithinemia: biochemical and histologic studies and response to vitamin B6. Kennaway, N.G., Weleber, R.G., Buist, N.R. Am. J. Hum. Genet. (1980)
- 31P nuclear magnetic resonance studies of glycogen phosphorylase from rabbit skeletal muscle: ionization states of pyridoxal 5'-phosphate. Feldmann, K., Hull, W.E. Proc. Natl. Acad. Sci. U.S.A. (1977)
- Gyrate atrophy of the choroid and retina: characterization of mutant ornithine aminotransferase and mechanism of response to vitamin B6. Kennaway, N.G., Stankova, L., Wirtz, M.K., Weleber, R.G. Am. J. Hum. Genet. (1989)
- Inhibition of erythrocyte sickling in vitro by pyridoxal. Kark, J.A., Kale, M.P., Tarassoff, P.G., Woods, M., Lessin, L.S. J. Clin. Invest. (1978)
- Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution. Clausen, T., Huber, R., Prade, L., Wahl, M.C., Messerschmidt, A. EMBO J. (1998)
- Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein. Meier, M., Janosik, M., Kery, V., Kraus, J.P., Burkhard, P. EMBO J. (2001)
- Sequence and structure of the dopa decarboxylase gene of Drosophila: evidence for novel RNA splicing variants. Eveleth, D.D., Gietz, R.D., Spencer, C.A., Nargang, F.E., Hodgetts, R.B., Marsh, J.L. EMBO J. (1986)
- Heterodimeric interactions among the 1-amino-cyclopropane-1-carboxylate synthase polypeptides encoded by the Arabidopsis gene family. Tsuchisaka, A., Theologis, A. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Purinergic receptor modulation of lipopolysaccharide signaling and inducible nitric-oxide synthase expression in RAW 264.7 macrophages. Hu, Y., Fisette, P.L., Denlinger, L.C., Guadarrama, A.G., Sommer, J.A., Proctor, R.A., Bertics, P.J. J. Biol. Chem. (1998)
- Ornithine decarboxylase from Saccharomyces cerevisiae. Purification, properties, and regulation of activity. Tyagi, A.K., Tabor, C.W., Tabor, H. J. Biol. Chem. (1981)
- Suppressors of the Ca(2+)-sensitive yeast mutant (csg2) identify genes involved in sphingolipid biosynthesis. Cloning and characterization of SCS1, a gene required for serine palmitoyltransferase activity. Zhao, C., Beeler, T., Dunn, T. J. Biol. Chem. (1994)
- Suppression of tumor growth and enhancement of immune status with high levels of dietary vitamin B6 in BALB/c mice. Gridley, D.S., Stickney, D.R., Nutter, R.L., Slater, J.M., Shultz, T.D. J. Natl. Cancer Inst. (1987)
- Regeneration of active enzyme by formation of hybrids from inactive derivatives: implications for active sites shared between polypeptide chains of aspartate transcarbamoylase. Robey, E.A., Schachman, H.K. Proc. Natl. Acad. Sci. U.S.A. (1985)
- Effects of DL-alpha-methylornithine on proliferation and polyamine content of 9L rat brain tumor cells. Seidenfeld, J., Marton, L.J. Cancer Res. (1980)
- Site-specific methylation of a strategic lysyl residue in aspartate aminotransferase. Roberts, W.J., Hubert, E., Iriarte, A., Martinez-Carrion, M. J. Biol. Chem. (1988)