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Gene Review:

wzyE - putative ECA polysaccharide chain...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3786, JW3769, rffT

Danese, P.N. et al., Erbel, P.J. et al.

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High impact information on wzyE

ECA(CYC) was not detected in mutant strains that possessed null mutations in the wecA, wecF, and wecG genes of the wec gene cluster [1].
Through this approach, we identified null mutations in the wecE, rmlAECA, and wecF loci that increase degP transcription [2].
Rather, the wecE, rmlAECA, and wecF null mutations each impede the same step in ECA biosynthesis, and it is the accumulation of the ECA biosynthetic intermediate, lipid II, that causes the observed perturbations [2].

References

Identification and biosynthesis of cyclic enterobacterial common antigen in Escherichia coli. Erbel, P.J., Barr, K., Gao, N., Gerwig, G.J., Rick, P.D., Gardner, K.H. J. Bacteriol. (2003) [Pubmed]
Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli. Danese, P.N., Oliver, G.R., Barr, K., Bowman, G.D., Rick, P.D., Silhavy, T.J. J. Bacteriol. (1998) [Pubmed]

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