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Gene Review

wecA  -  UDP-GlcNAc:undecaprenylphosphate GlcNAc-1...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3776, JW3758, rfe
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Disease relevance of rfe

  • The Escherichia coli O8 antigen is a mannan composed of the trisaccharide repeat unit -->3)-alpha-Man-(1-->2)-alpha-Man-(1-->2)-alpha-Man-(1--> (K. Reske and K. Jann, Eur. J. Biochem. 67:53-56, 1972), and synthesis of the O8 antigen is rfe dependent (G. Schmidt, H. Mayer, and P. H. Mäkelä, J. Bacteriol. 127:755-762, 1976) [1].

High impact information on rfe


Chemical compound and disease context of rfe

  • The rfe-defective mutant of S. typhimurium synthesized only very small amounts of E. coli O9 LPS after the introduction of E. coli O9 rfb [4].

Biological context of rfe


Associations of rfe with chemical compounds


Other interactions of rfe

  • Replacement of sequences B-F with prokaryotic counterparts from either the B.subtilis mraY or E.coli rfe genes also affected GPT by preventing expression of the mutant protein (B, F) or inhibiting its enzymatic activity (C-E) [5].
  • Synthesis of D-galactan I was dependent on chromosomal galE and rfe genes [6].

Analytical, diagnostic and therapeutic context of rfe


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