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Gene Review:

fdhE - formate dehydrogenase formation protein

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3884, JW3862

Mandrand-Berthelot, M.A. et al., Stewart, V. et al.

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Disease relevance of fdhE

Analogous mutants, termed fdhD and fdhE, have been isolated in Escherichia coli [1].

Chemical compound and disease context of fdhE

Genetic evidence that genes fdhD and fdhE do not control synthesis of formate dehydrogenase-N in Escherichia coli K-12 [1].

Biological context of fdhE

Construction of merodiploid strains harbouring various combinations of the mutated alleles, fdhE on the episome and fdhD on the chromosome, led to the restoration of FDH-PMS activity by complementation of the products encoded by the respective wild-type alleles [2].

Associations of fdhE with chemical compounds

Difference spectroscopy suggested that both fdhD and fdhE mutants contained normal amounts of the cytochrome b559 associated with FDH-PMS although the cytochrome had lost its capacity for formate-dependent reduction [2].

References

Genetic evidence that genes fdhD and fdhE do not control synthesis of formate dehydrogenase-N in Escherichia coli K-12. Stewart, V., Lin, J.T., Berg, B.L. J. Bacteriol. (1991) [Pubmed]
Mutants of Escherichia coli specifically deficient in respiratory formate dehydrogenase activity. Mandrand-Berthelot, M.A., Couchoux-Luthaud, G., Santini, C.L., Giordano, G. J. Gen. Microbiol. (1988) [Pubmed]

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