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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

cdh  -  CDP-diacylglycerol phosphotidylhydrolase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3910, JW3889, pnuE, ushB
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Disease relevance of cdh

  • Previous work from this laboratory had demonstrated that CDP-diglyceride hydrolase of Escherichia coli is encoded by the cdh gene that maps near minute 88 (Bulawa, C. E., and Raetz, C. R. H. (1984) J. Biol. Chem. 259, 11257-11264) [1].

High impact information on cdh

  • The molecular weight of the primary translation product deduced from the DNA sequence of the cdh gene is 28,450, in agreement with maxicell experiments [1].
  • We now report the construction of hybrid plasmids and the sequencing of a 1,243-base pair insert carrying cdh [1].
  • (iii) Mutants in the cdh gene are defective in both CDP- and dCDP-diglyceride hydrolysis, while cdh clones overproduce both activities [2].
  • The isolation of deletion and Tn10 insertion mutants at cdh suggests that the hydrolase is nonessential for cell growth [2].

Biological context of cdh

  • Hydrolase mutants are defective in both CDP-diglyceride hydrolysis and CDP-diglyceride-dependent cytidylylation, indicating that both activities are encoded by the cdh gene [2].


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