The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

Table of contents

About

Terms

 

Gene Review: 

cdh  -  CDP-diacylglycerol phosphotidylhydrolase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3910, JW3889, pnuE, ushB
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of cdh

  • Previous work from this laboratory had demonstrated that CDP-diglyceride hydrolase of Escherichia coli is encoded by the cdh gene that maps near minute 88 (Bulawa, C. E., and Raetz, C. R. H. (1984) J. Biol. Chem. 259, 11257-11264) [1].
 

High impact information on cdh

  • The molecular weight of the primary translation product deduced from the DNA sequence of the cdh gene is 28,450, in agreement with maxicell experiments [1].
  • We now report the construction of hybrid plasmids and the sequencing of a 1,243-base pair insert carrying cdh [1].
  • (iii) Mutants in the cdh gene are defective in both CDP- and dCDP-diglyceride hydrolysis, while cdh clones overproduce both activities [2].
  • The isolation of deletion and Tn10 insertion mutants at cdh suggests that the hydrolase is nonessential for cell growth [2].
 

Biological context of cdh

  • Hydrolase mutants are defective in both CDP-diglyceride hydrolysis and CDP-diglyceride-dependent cytidylylation, indicating that both activities are encoded by the cdh gene [2].

References

  1. Molecular cloning and sequencing of the gene for CDP-diglyceride hydrolase of Escherichia coli. Icho, T., Bulawa, C.E., Raetz, C.R. J. Biol. Chem. (1985) [Pubmed]
  2. Isolation and characterization of Escherichia coli strains defective in CDP-diglyceride hydrolase. Bulawa, C.E., Raetz, C.R. J. Biol. Chem. (1984) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities