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Gene Review

phnP  -  5-phospho-alpha-D-ribosyl 1,2-cyclic...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4085, JW4053
 
 
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Disease relevance of phnP

  • On the basis of mutational analysis, the genes for phosphonate uptake and degradation in Escherichia coli were shown to be organized in a 10.9-kb operon of 14 genes (named phnC to phnP) and induced by phosphate (P(i)) starvation [Metcalf and Wanner (1993) J Bacteriol 175: 3430-3442] [1].
 

High impact information on phnP

  • Studies of the structure, regulation, and function of the phn region suggest that the phosphate starvation-inducible phn operon consists of 14 cistrons from phnC to phnP [2].
  • As expected for genes involved in P acquisition, the phnC-phnP operon is a member of the PHO regulon and is induced many hundred-fold during phosphate limitation [3].
 

Biological context of phnP

References

  1. Phosphate-independent expression of the carbon-phosphorus lyase activity of Escherichia coli. Yakovleva, G.M., Kim, S.K., Wanner, B.L. Appl. Microbiol. Biotechnol. (1998) [Pubmed]
  2. Molecular analysis of the cryptic and functional phn operons for phosphonate use in Escherichia coli K-12. Makino, K., Kim, S.K., Shinagawa, H., Amemura, M., Nakata, A. J. Bacteriol. (1991) [Pubmed]
  3. Molecular genetic studies of a 10.9-kb operon in Escherichia coli for phosphonate uptake and biodegradation. Wanner, B.L., Metcalf, W.W. FEMS Microbiol. Lett. (1992) [Pubmed]
 
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