Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

cadB - putative lysine/cadaverine transporter

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4126, JW4093

Meng, S.Y. et al., Merrell, D.S. et al., Watson, N. et al.

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Disease relevance of cadB

Unlike in Escherichia coli, V. cholerae cadB and cadA are also transcribed monocistronically [1].

Biological context of cadB

Deletion analysis of the upstream region and cloning of various fragments to make cadA::lacZ or cadB::lacZ protein fusions or operon fusions showed that cadA was translated more efficiently than cadB and localized the pH-responsive site to a region near an upstream EcoRV site [2].

Other interactions of cadB

One of these, cadB, is 444 codons long and is situated immediately upstream of cadA [3].

References

Regulation of vibrio cholerae genes required for acid tolerance by a member of the "ToxR-like" family of transcriptional regulators. Merrell, D.S., Camilli, A. J. Bacteriol. (2000) [Pubmed]
Regulation of the Escherichia coli cad operon: location of a site required for acid induction. Meng, S.Y., Bennett, G.N. J. Bacteriol. (1992) [Pubmed]
Identification of elements involved in transcriptional regulation of the Escherichia coli cad operon by external pH. Watson, N., Dunyak, D.S., Rosey, E.L., Slonczewski, J.L., Olson, E.R. J. Bacteriol. (1992) [Pubmed]

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