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Gene Review:

rimI - ribosomal-protein-S18-alanine N...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4364, JW4335

Carter, J.R. et al., Tanaka, S. et al., Yoshikawa, A. et al., Isono, K. et al.

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Disease relevance of rimI

The rimI gene of Escherichia coli K12, which encodes an enzyme catalysing acetylation of the N-terminal alanine of ribosomal protein S18, has been cloned into a mini-F plasmid pRE432 and characterized at the molecular level [1].

High impact information on rimI

The gene, which maps to 99.3 centisomes, was sequenced and found to be identical to a previously uncharacterized open reading frame that overlaps the 5' end of rimI by 29 bases, contains 411 bp, and is predicted to encode a protein of 15,174 Da [2].
The nucleotide sequence of the gene and the amino acid sequence deduced from the nucleotide sequence were compared with those of two other ribosomal protein acetylases encoded by the rimI and rimJ genes (Yoshikawa et al. 1987) [3].
The gene which is affected in this mutant is termed rimI that most likely specifies an enzyme acetylating the N-terminal alanine of protein S18 [4].

References

Cloning and nucleotide sequencing of the genes rimI and rimJ which encode enzymes acetylating ribosomal proteins S18 and S5 of Escherichia coli K12. Yoshikawa, A., Isono, S., Sheback, A., Isono, K. Mol. Gen. Genet. (1987) [Pubmed]
Identification, isolation, and overexpression of the gene encoding the psi subunit of DNA polymerase III holoenzyme. Carter, J.R., Franden, M.A., Aebersold, R., McHenry, C.S. J. Bacteriol. (1993) [Pubmed]
Cloning and molecular characterization of the gene rimL which encodes an enzyme acetylating ribosomal protein L12 of Escherichia coli K12. Tanaka, S., Matsushita, Y., Yoshikawa, A., Isono, K. Mol. Gen. Genet. (1989) [Pubmed]
Ribosomal protein modification in Escherichia coli. II. Studies of a mutant lacking the N-terminal acetylation of protein S18. Isono, K., Isono, S. Mol. Gen. Genet. (1980) [Pubmed]

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