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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SLC4A8  -  solute carrier family 4, sodium...

Homo sapiens

Synonyms: Electroneutral Na(+)-driven Cl-HCO3 exchanger, Electroneutral sodium bicarbonate exchanger 1, KIAA0739, NBC, NBC3, ...
 
 
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High impact information on SLC4A8

  • This human gene (SLC4A8) maps to chromosome 12q13 [1].
  • The NBC3 gene (SLC4A7) spans approximately 80 kb and is composed of 25 coding exons and 24 introns that are flanked by typical splice donor and acceptor sequences [2].
  • Although NBC3 immunoreactivity was also detected in submandibular gland acinar cells and in the ducts of both glands, it is unlikely that NBC3 plays any role in pH(i) regulation [3].
  • At the amino acid level, NBC4c is 56% identical to NBC1 protein variants and 40% identical to electroneutral NBC3 [4].
  • This is also the case for the SLC4A8 and SLC4A10 gene products, which are sodium dependent Cl(-), HCO(3) (-) exchangers [5].

References

  1. Cloning, characterization, and chromosomal mapping of a human electroneutral Na(+)-driven Cl-HCO3 exchanger. Grichtchenko, I.I., Choi, I., Zhong, X., Bray-Ward, P., Russell, J.M., Boron, W.F. J. Biol. Chem. (2001) [Pubmed]
  2. Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family. Pushkin, A., Abuladze, N., Lee, I., Newman, D., Hwang, J., Kurtz, I. J. Biol. Chem. (1999) [Pubmed]
  3. Expression of the Na+-HCO3- cotransporter and its role in pHi regulation in guinea pig salivary glands. Li, J., Koo, N.Y., Cho, I.H., Kwon, T.H., Choi, S.Y., Lee, S.J., Oh, S.B., Kim, J.S., Park, K. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  4. Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter. Sassani, P., Pushkin, A., Gross, E., Gomer, A., Abuladze, N., Dukkipati, R., Carpenito, G., Kurtz, I. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
  5. Sodium coupled bicarbonate transporters in the kidney, an update. Aalkjaer, C., Frische, S., Leipziger, J., Nielsen, S., Praetorius, J. Acta Physiol. Scand. (2004) [Pubmed]
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