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MeSH Review

Submandibular Gland

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Disease relevance of Submandibular Gland


High impact information on Submandibular Gland

  • Thus the liver and submaxillary gland synthesize alpha 2u globulin from different sets of genes that are subject to very different developmental and hormonal control [6].
  • The renin regulatory locus (Rnr) is a genetic element governing mouse submaxillary gland (SMG) renin levels [7].
  • Immunocytochemical studies have revealed the presence of EGF in mouse and human submaxillary glands, rat brain and human intestine [8].
  • Tonin, an esteroprotease isolated from rat submaxillary gland, is a serine protease with trypsin- and chymotrypsin-like activity [9].
  • While NGF is found in almost all vertebrates, most research has focused on murine NGF, as the mouse male submaxillary gland contains higher levels of this polypeptide than other tissues [10].

Chemical compound and disease context of Submandibular Gland


Biological context of Submandibular Gland


Anatomical context of Submandibular Gland


Associations of Submandibular Gland with chemical compounds


Gene context of Submandibular Gland


Analytical, diagnostic and therapeutic context of Submandibular Gland


  1. Sialic acid glycoproteins inhibit in vitro and in vivo replication of rotaviruses. Yolken, R.H., Willoughby, R., Wee, S.B., Miskuff, R., Vonderfecht, S. J. Clin. Invest. (1987) [Pubmed]
  2. Epidermal growth factor deficiency associated with diabetes mellitus. Kasayama, S., Ohba, Y., Oka, T. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  3. The effect of lymphoma and other neoplasms on hepatic and plasma enzymes of the host rat. Herzfeld, A., Greengard, O. Cancer Res. (1977) [Pubmed]
  4. Immunization of colorectal cancer patients with modified ovine submaxillary gland mucin and adjuvants induces IgM and IgG antibodies to sialylated Tn. O'Boyle, K.P., Zamore, R., Adluri, S., Cohen, A., Kemeny, N., Welt, S., Lloyd, K.O., Oettgen, H.F., Old, L.J., Livingston, P.O. Cancer Res. (1992) [Pubmed]
  5. Effect of sialoadenectomy and synthetic human urogastrone on healing of chronic gastric ulcers in rats. Olsen, P.S., Poulsen, S.S., Therkelsen, K., Nexø, E. Gut (1986) [Pubmed]
  6. Tissue-specific control of alpha 2u globulin gene expression: constitutive synthesis in the submaxillary gland. Laperche, Y., Lynch, K.R., Dolan, K.P., Feigelson, P. Cell (1983) [Pubmed]
  7. A DNA polymorphism, consistent with gene duplication, correlates with high renin levels in the mouse submaxillary gland. Piccini, N., Knopf, J.L., Gross, K.W. Cell (1982) [Pubmed]
  8. Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues. Rall, L.B., Scott, J., Bell, G.I., Crawford, R.J., Penschow, J.D., Niall, H.D., Coghlan, J.P. Nature (1985) [Pubmed]
  9. Amino acid sequence of rat submaxillary tonin reveals similarities to serine proteases. Lazure, C., Leduc, R., Seidah, N.G., Thibault, G., Genest, J., Chrétien, M. Nature (1984) [Pubmed]
  10. Human beta-nerve growth factor gene sequence highly homologous to that of mouse. Ullrich, A., Gray, A., Berman, C., Dull, T.J. Nature (1983) [Pubmed]
  11. Testosterone-induced suppression of autoimmune disease in lacrimal tissue of a mouse model (NZB/NZW F1) of Sjögren's syndrome. Vendramini, A.C., Soo, C., Sullivan, D.A. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
  12. Thyroxine reverses deficits of nerve growth factor and epidermal growth factor in submandibular glands of mice with muscular dystrophy. Watson, A.Y., Radie, K., McCarthy, M., Larsen, P.R., Murphy, R.A. Endocrinology (1982) [Pubmed]
  13. Characterization of a prostate carcinoma mucin-like antigen (PMA). Beckett, M.L., Wright, G.L. Int. J. Cancer (1995) [Pubmed]
  14. Unexpected beta adrenergic effects of the antitumor agent, cyclocytidine, on rat salivary glands. Schneyer, C.A., Galbraith, W.M., Mellett, L.B. Proc. Soc. Exp. Biol. Med. (1975) [Pubmed]
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  16. Cloning and cDNA sequence of a bovine submaxillary gland mucin-like protein containing two distinct domains. Bhargava, A.K., Woitach, J.T., Davidson, E.A., Bhavanandan, V.P. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  17. New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues. Roberts, A.B., Anzano, M.A., Lamb, L.C., Smith, J.M., Sporn, M.B. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  18. Nerve growth factor: activation of the classical complement pathway by specific substitution for component C1-. Boyle, M.D., Young, M. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  19. Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse. Wilson, C.M., Erdös, E.G., Wilson, J.D., Taylor, B.A. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  20. Role of the autonomic nervous system in the release of rat submandibular gland kallikrein into the circulation. Rabito, S.F., Orstavik, T.B., Scicli, A.G., Schork, A., Carretero, O.A. Circ. Res. (1983) [Pubmed]
  21. Various enzyme activities in muscle and other organs of dystrophic mice. Aoyagi, T., Wada, T., Kojima, F., Nagai, M., Umezawa, H. J. Clin. Invest. (1981) [Pubmed]
  22. Apical vesicles bearing inositol 1,4,5-trisphosphate receptors in the Ca2+ initiation site of ductal epithelium of submandibular gland. Yamamoto-Hino, M., Miyawaki, A., Segawa, A., Adachi, E., Yamashina, S., Fujimoto, T., Sugiyama, T., Furuichi, T., Hasegawa, M., Mikoshiba, K. J. Cell Biol. (1998) [Pubmed]
  23. Fusion of the envelope of mucous droplets with the luminal plasma membrane in acinar cells of the cat submandibular gland. Tandler, B., Poulsen, J.H. J. Cell Biol. (1976) [Pubmed]
  24. Regulated expression of the Ren-2 gene in transgenic mice derived from parental strains carrying only the Ren-1 gene. Tronik, D., Dreyfus, M., Babinet, C., Rougeon, F. EMBO J. (1987) [Pubmed]
  25. Production of EGF-containing polypeptides in Xenopus oocytes microinjected with submaxillary gland mRNA. Burmeister, M., Avivi, A., Schlessinger, J., Soreq, H. EMBO J. (1984) [Pubmed]
  26. A physiological role of epidermal growth factor in male reproductive function. Tsutsumi, O., Kurachi, H., Oka, T. Science (1986) [Pubmed]
  27. Role of submandibular saliva and epidermal growth factor in gastric cytoprotection. Olsen, P.S., Poulsen, S.S., Kirkegaard, P., Nexø, E. Gastroenterology (1984) [Pubmed]
  28. The mouse Rn locus: S allele of the renin regulator gene results from a single structural gene duplication. Panthier, J.J., Holm, I., Rougeon, F. EMBO J. (1982) [Pubmed]
  29. Modulation of proline-rich protein biosynthesis in rat parotid glands by sorghums with high tannin levels. Mehansho, H., Hagerman, A., Clements, S., Butler, L., Rogler, J., Carlson, D.M. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  30. Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms. Hoffman, M.P., Kidder, B.L., Steinberg, Z.L., Lakhani, S., Ho, S., Kleinman, H.K., Larsen, M. Development (2002) [Pubmed]
  31. FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Steinberg, Z., Myers, C., Heim, V.M., Lathrop, C.A., Rebustini, I.T., Stewart, J.S., Larsen, M., Hoffman, M.P. Development (2005) [Pubmed]
  32. Tissue kallikrein and tonin levels in submandibular glands of STZ-induced diabetic rats and the effects of insulin. Chan, K.M., Chao, J., Proctor, G.B., Garrett, J.R., Shori, D.K., Anderson, L.C. Diabetes (1993) [Pubmed]
  33. Characteristic multiorgan pathology of cystic fibrosis in a long-living cystic fibrosis transmembrane regulator knockout murine model. Durie, P.R., Kent, G., Phillips, M.J., Ackerley, C.A. Am. J. Pathol. (2004) [Pubmed]
  34. Expression of S-100 protein and glial fibrillary acidic protein in cultured submandibular gland epithelial cells and salivary gland tissues. Histogenetic implication for salivary gland tumors. Okura, M., Hiranuma, T., Tominaga, G., Yoshioka, H., Aikawa, T., Shirasuna, K., Matsuya, T. Am. J. Pathol. (1996) [Pubmed]
  35. Molecular characterization of a functional cDNA encoding the rat substance P receptor. Hershey, A.D., Krause, J.E. Science (1990) [Pubmed]
  36. Secretion of a nerve growth factor by mouse neuroblastoma cells in culture. Murphy, R.A., Pantazis, N.J., Arnason, B.G., Young, M. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  37. Characterization of common salivary protein 1, a product of rat submandibular, sublingual, and parotid glands. Girard, L.R., Castle, A.M., Hand, A.R., Castle, J.D., Mirels, L. J. Biol. Chem. (1993) [Pubmed]
  38. Mouse submandibular gland prorenin-converting enzyme is a member of glandular kallikrein family. Kim, W.S., Nakayama, K., Nakagawa, T., Kawamura, Y., Haraguchi, K., Murakami, K. J. Biol. Chem. (1991) [Pubmed]
  39. Purification to homogeneity of a beta-galactoside alpha2 leads to 3 sialyltransferase and partial purification of an alpha-N-acetylgalactosaminide alpha2 leads to 6 sialyltransferase from porcine submaxillary glands. Sadler, J.E., Rearick, J.I., Paulson, J.C., Hill, R.L. J. Biol. Chem. (1979) [Pubmed]
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