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Gene Review

yjeE  -  hypothetical protein

Haemophilus influenzae Rd KW20

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High impact information on yjeE

  • Treatment with the ATPase inhibitor Novobiocin changed the expression rates of many genes, reflecting the fact that the initiation of transcription for many genes is sensitive to DNA supercoiling [1].
  • A stable enzyme-DNA complex is formed as demonstrated by co-sedimentation of DNA and ATPase activity in sucrose gradients [2].
  • A structure-guided drug design approach was used to optimize a novel series of aminobenzimidazoles that inhibit the essential ATPase activities of bacterial DNA gyrase and topoisomerase IV and that show potent activities against a variety of bacterial pathogens [3].
  • We conclude that extra supercoiling enhanced transcription of the alkaline phosphatase gene but not the ATPase gene and that it is unlikely that there is much discrepancy between gyrase activity assayed in vitro and the activity in the cell [4].
  • Sensitivity to mitomycin C and deoxycholate and complementation between extracts and deoxyribonucleic acid (DNA)-dependent ATPase activity have been measured [5].


  1. Gene expression changes triggered by exposure of Haemophilus influenzae to novobiocin or ciprofloxacin: combined transcription and translation analysis. Gmuender, H., Kuratli, K., Di Padova K, n.u.l.l., Gray, C.P., Keck, W., Evers, S. Genome Res. (2001) [Pubmed]
  2. Action of ATP-dependent DNase from Hemophilus influenzae on cross-linked DNA molecules. Orlosky, M., Smith, H.O. J. Biol. Chem. (1976) [Pubmed]
  3. Dual Targeting of GyrB and ParE by a Novel Aminobenzimidazole Class of Antibacterial Compounds. Grossman, T.H., Bartels, D.J., Mullin, S., Gross, C.H., Parsons, J.D., Liao, Y., Grillot, A.L., Stamos, D., Olson, E.R., Charifson, P.S., Mani, N. Antimicrob. Agents Chemother. (2007) [Pubmed]
  4. Gyrase activity and number of copies of the gyrase B subunit gene in Haemophilus influenzae. Cabrera-Juárez, E., Setlow, J.K. J. Bacteriol. (1985) [Pubmed]
  5. Genetics and complementation of Haemophilus influenzae mutants deficient in adenosine 5'-triphosphate-dependent nuclease. Kooistra, J., Small, G.D., Setlow, J.K., Shapanka, R. J. Bacteriol. (1976) [Pubmed]
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