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Gene Review

dapB  -  dihydrodipicolinate reductase

Escherichia coli O157:H7 str. EDL933

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Disease relevance of dapB

  • Based on this and our previous results, we constructed an L-lysine-producing strain of M. methylotrophus by introducing well-characterized genes encoding desensitized forms of AK and DDPS, as well as dapB (encoding DDPR) from Escherichia coli, using a broad host range plasmid [1].

High impact information on dapB

  • DDPR was markedly inhibited by L-lysine [1].
  • To elucidate further the regulation of L-lysine biosynthesis in M. methylotrophus, we cloned the genes encoding three other enzymes involved in this pathway, L-aspartate-beta-semialdehyde dehydrogenase, dihydrodipicolinate reductase (DDPR) and diaminopimelate decarboxylase, and examined their properties [1].


  1. L-Lysine biosynthetic pathway of Methylophilus methylotrophus and construction of an L-lysine producer. Tsujimoto, N., Gunji, Y., Ogawa-Miyata, Y., Shimaoka, M., Yasueda, H. J. Biotechnol. (2006) [Pubmed]
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