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Gene Review

dapA  -  dihydrodipicolinate synthase

Escherichia coli CFT073

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Disease relevance of dapA


Associations of dapA with chemical compounds

  • DHDPS (dihydrodipicolinate synthase) catalyses the branch point in lysine biosynthesis in bacteria and plants and is feedback inhibited by lysine [2].


  1. L-Lysine biosynthetic pathway of Methylophilus methylotrophus and construction of an L-lysine producer. Tsujimoto, N., Gunji, Y., Ogawa-Miyata, Y., Shimaoka, M., Yasueda, H. J. Biotechnol. (2006) [Pubmed]
  2. Dihydrodipicolinate synthase from Thermotoga maritima. Pearce, F.G., Perugini, M.A., McKerchar, H.J., Gerrard, J.A. Biochem. J. (2006) [Pubmed]
  3. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of DapA (Rv2753c) from Mycobacterium tuberculosis. Kefala, G., Weiss, M.S. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
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