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Gene Review

entE  -  enterobactin synthase subunit E

Escherichia coli O157:H7 str. EDL933

 
 
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Disease relevance of entE

 

High impact information on entE

  • There was 84% nucleotide sequence homology between entE and the gene for staphylococcal enterotoxin type A; these genes encoded protein products that had 214 (83%) homologous amino acid residues (mature forms had 188 [82%] homologous amino acid residues) [1].
  • The entE gene contained 771 base pairs that encoded a protein with a molecular weight of 29,358 which was apparently processed to a mature extracellular form with a molecular weight of 26,425 [1].
  • 2,3-Dihydroxybenzohydroxamoyl adenylate (I) was prepared as a potential product analog inhibitor of EntE (EC# 2.7.7.58), a 2,3-dihydroxybenzoate AMP ligase from Escherichia coli that is required for the biosynthesis of enterobactin [2].

References

  1. Cloning and nucleotide sequence of the type E staphylococcal enterotoxin gene. Couch, J.L., Soltis, M.T., Betley, M.J. J. Bacteriol. (1988) [Pubmed]
  2. Nanomolar inhibition of the enterobactin biosynthesis enzyme, EntE: synthesis, substituent effects, and additivity. Callahan, B.P., Lomino, J.V., Wolfenden, R. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
 
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