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Gene Review

CREB5  -  cAMP responsive element binding protein 5

Homo sapiens

Synonyms: CRE-BPA, CRE-BPa, CREB-5, CREBPA, Cyclic AMP-responsive element-binding protein 5, ...
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High impact information on CREB5

  • Expression of CRE-BPa mRNA was found in a limited number of cell lines, and multiple sizes of CRE-BPa mRNA species were detected in some cell lines and tissues [1].
  • CRE-BPa will be useful to clarify the mechanism of CRE-mediated transcriptional activation by E1A or c-Jun [1].
  • CRE-BPa alpha has four regions highly homologous to CRE-BP1, including a putative metal finger structure and a DNA-binding domain consisting of a basic amino acid cluster and a leucine zipper [2].


  1. Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1. Nomura, N., Zu, Y.L., Maekawa, T., Tabata, S., Akiyama, T., Ishii, S. J. Biol. Chem. (1993) [Pubmed]
  2. Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA. Zu, Y.L., Maekawa, T., Nomura, N., Nakata, T., Ishii, S. Oncogene (1993) [Pubmed]
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