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Gene Review:

Z1640 - hypothetical protein

Escherichia coli O157:H7 str. EDL933

Shen, S. et al.

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Disease relevance of Z1640

In a PCR investigation of 36 VTEC strains of different serotypes, intact Z1640 was present in strains of serotypes O157:H7, O26:H11, O103:H2, O111:NM, and O145:NM, which are associated with hemolytic uremic syndrome and outbreaks [1].

High impact information on Z1640

In contrast, fragmented Z1640 was seen in strains of nonepidemic serotypes, such as O91:H21 and O113:H21, and in animal serotypes that have not been associated with human disease, indicating that Z1640 might be a virulence gene [1].

References

Evidence for a hybrid genomic island in verocytotoxin-producing Escherichia coli CL3 (serotype O113:H21) containing segments of EDL933 (serotype O157:H7) O islands 122 and 48. Shen, S., Mascarenhas, M., Rahn, K., Kaper, J.B., Karmali, M.A., Karmal, M.A. Infect. Immun. (2004) [Pubmed]

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