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Gene Review:

def - peptide deformylase

Escherichia coli O157:H7 str. EDL933

Teo, J.W. et al.

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Disease relevance of def

Essentiality of the def gene, encoding PDF from Mycobacterium tuberculosis, was demonstrated through genetic knockout experiments with Mycobacterium bovis BCG [1].
PDF from M. tuberculosis strain H37Rv was cloned, expressed, and purified as an N-terminal histidine-tagged recombinant protein in Escherichia coli [1].

High impact information on def

A novel class of PDF inhibitors (PDF-I), the N-alkyl urea hydroxamic acids, were synthesized and evaluated for their activities against the M. tuberculosis PDF enzyme as well as their antimycobacterial effects [1].
Peptide deformylase (PDF) catalyzes the hydrolytic removal of the N-terminal formyl group from nascent proteins [1].

References

Peptide deformylase inhibitors as potent antimycobacterial agents. Teo, J.W., Thayalan, P., Beer, D., Yap, A.S., Nanjundappa, M., Ngew, X., Duraiswamy, J., Liung, S., Dartois, V., Schreiber, M., Hasan, S., Cynamon, M., Ryder, N.S., Yang, X., Weidmann, B., Bracken, K., Dick, T., Mukherjee, K. Antimicrob. Agents Chemother. (2006) [Pubmed]

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