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Gene Review

MORF4L2  -  mortality factor 4 like 2

Homo sapiens

Synonyms: KIAA0026, MORF-related gene X protein, MORFL2, MRGX, Mortality factor 4-like protein 2, ...
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High impact information on MORF4L2

  • MRGX interacts with Rb through the helix-loop-helix and leucine zipper regions [1].
  • MRGX is a novel transcription factor that is a member of the mortality factor 4 (MORF4)-related gene family [1].
  • Interestingly, MRGX repressed the B-myb promoter in EJ cells (human bladder carcinoma cells), which have a functional Rb, but activated B-myb in HeLa cells (human cervical carcinoma cells), which express a lower amount of Rb [1].

Other interactions of MORF4L2

  • This repression and activation was dependent on the helix-loop-helix and leucine zipper regions of the MRGX protein but not the N-terminal region [1].


  1. MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. Tominaga, K., Leung, J.K., Rookard, P., Echigo, J., Smith, J.R., Pereira-Smith, O.M. J. Biol. Chem. (2003) [Pubmed]
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