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Gene Review

MORF4  -  mortality factor 4

Homo sapiens

Synonyms: CSR, CSRB, SEN, SEN1
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Disease relevance of MORF4


Psychiatry related information on MORF4

  • METHODS: Polysomnograms with digitized video surveillance of 20 consecutive patients with heart failure and CSA-CSR were analyzed for total apnea-hypopnea index, mean event duration, and mean oxygen desaturation according to sleep stage and position [5].
  • Specifically, presence of coexistent depression accounted for 17% of the variance in clinician severity ratings (CSR; P < .01), with individuals diagnosed with a comorbid mood disorder receiving higher clinician severity ratings [6].

High impact information on MORF4

  • Genome-Wide Distribution of Yeast RNA Polymerase II and Its Control by Sen1 Helicase [7].
  • Remarkably, a single amino acid substitution that compromises Sen1 function causes profound changes in Pol II distribution over both noncoding and protein-coding genes, establishing an important function of Sen1 in the regulation of transcription [7].
  • We assessed whether coinfection of patients with chronic hepatitis C and SEN D or SEN H correlates with the outcome of treatment with interferon and ribavirin [1].
  • Two AS cases carrying SEN had low Hb F and low F cells, while three AS and one CS carrying BEN had elevated Hb F and elevated F cells; only one AS carrying BEN had low Hb F and low F cells [3].
  • We report the cloning and identification of a gene, mortality factor 4 (MORF 4), which induces a senescent-like phenotype in immortal cell lines assigned to complementation group B with concomitant changes in two markers for senescence [8].

Chemical compound and disease context of MORF4


Biological context of MORF4


Anatomical context of MORF4


Associations of MORF4 with chemical compounds

  • Mortality Factor on Chromosome 4 (MORF4) induces senescence in several immortal human cell lines [22].
  • Both the C-terminal lysine residue of SEN and a region N-terminal to it play a critical role in plasminogen binding [23].
  • CSR and 17OHCS excretions were not different from age controls, but were significantly lower than size controls, THF/THE ratios, urinary excretion of free corticoids and cortisol were normal [24].
  • Oral CS decreased CD3+ cell counts (medians: 60-20 cells/mm(2); P = 0.014) and MBP+ cell counts (medians: 19-4 cells/mm(2); P = 0.03) in CSS asthmatics, but only tryptase+ cell counts in CSR asthmatics (medians: 30-18 cells/mm(2); P = 0.05) [25].
  • In the light of this, SEN specimens of heat-cured denture-base PMMA were saturated in a range of liquids and extended to failure at chewing speed [26].

Other interactions of MORF4


Analytical, diagnostic and therapeutic context of MORF4


  1. Effect on treatment outcome of coinfection with SEN viruses in patients with hepatitis C. Rigas, B., Hasan, I., Rehman, R., Donahue, P., Wittkowski, K.M., Lebovics, E. Lancet (2001) [Pubmed]
  2. SEN and sensibility: interactions between newly discovered and other hepatitis viruses? Di Bisceglie, A.M. Lancet (2001) [Pubmed]
  3. G gamma and A gamma globin genes are identical from -471 of the promoter midway through gamma IVSII in a Benin beta s haplotype associated with elevated fetal hemoglobin. Mishima, N., Brinson, E.C., Milner, P.F., Gilman, J.G. Am. J. Hum. Genet. (1991) [Pubmed]
  4. SEN virus infection and its relationship to transfusion-associated hepatitis. Umemura, T., Yeo, A.E., Sottini, A., Moratto, D., Tanaka, Y., Wang, R.Y., Shih, J.W., Donahue, P., Primi, D., Alter, H.J. Hepatology (2001) [Pubmed]
  5. Lateral sleeping position reduces severity of central sleep apnea / Cheyne-Stokes respiration. Szollosi, I., Roebuck, T., Thompson, B., Naughton, M.T. Sleep. (2006) [Pubmed]
  6. Generalized anxiety disorder in older adults: examining the relation between clinician severity ratings and patient self-report measures. Hopko, D.R., Bourland, S.L., Stanley, M.A., Beck, J.G., Novy, D.M., Averill, P.M., Swann, A.C. Depression and anxiety. (2000) [Pubmed]
  7. Genome-Wide Distribution of Yeast RNA Polymerase II and Its Control by Sen1 Helicase. Steinmetz, E.J., Warren, C.L., Kuehner, J.N., Panbehi, B., Ansari, A.Z., Brow, D.A. Mol. Cell (2006) [Pubmed]
  8. Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. Bertram, M.J., Bérubé, N.G., Hang-Swanson, X., Ran, Q., Leung, J.K., Bryce, S., Spurgers, K., Bick, R.J., Baldini, A., Ning, Y., Clark, L.J., Parkinson, E.K., Barrett, J.C., Smith, J.R., Pereira-Smith, O.M. Mol. Cell. Biol. (1999) [Pubmed]
  9. Isolation of a human intestinal anaerobe, Bifidobacterium sp. strain SEN, capable of hydrolyzing sennosides to sennidins. Akao, T., Che, Q.M., Kobashi, K., Yang, L., Hattori, M., Namba, T. Appl. Environ. Microbiol. (1994) [Pubmed]
  10. A cross-sectional study of SEN virus in liver transplant recipients. Yoshida, E.M., Buczkowski, A.K., Giulivi, A., Zou, S., Forrester, L.A. Liver Transpl. (2001) [Pubmed]
  11. Dent's disease and prevalence of renal stones in dialysis patients in Northeastern Italy. Tosetto, E., Graziotto, R., Artifoni, L., Nachtigal, J., Cascone, C., Conz, P., Piva, M., Dell'Aquila, R., De Paoli Vitali, E., Citron, L., Nalesso, F., Antonello, A., Vertolli, U., Zagatti, R., Lupo, A., D'Angelo, A., Anglani, F., Gambaro, G. J. Hum. Genet. (2006) [Pubmed]
  12. A sennoside-hydrolyzing beta-glucosidase from Bifidobacterium sp. strain SEN is inducible. Yang, L., Akao, T., Kobashi, K., Hattori, M. Biol. Pharm. Bull. (1996) [Pubmed]
  13. Decrease in Fungizone toxicity induced by the use of Lipofundin as a dilutent: an in vitro study. de Araújo, I.B., Damasceno, B.P., de Medeiros, T.M., Soares, L.A., do Egito, E.S. Current drug delivery. (2005) [Pubmed]
  14. Genetic approaches to the study of replicative senescence. Ran, Q., Pereira-Smith, O.M. Exp. Gerontol. (2000) [Pubmed]
  15. Genetic and functional analyses exclude mortality factor 4 (MORF4) as a keratinocyte senescence gene. Bryce, S.D., Forsyth, N.R., Fitzsimmons, S.A., Clark, L.J., Bertram, M.J., Cuthbert, A.P., Newbold, R.F., Pereira-Smith, O.M., Parkinson, E.K. Cancer Res. (1999) [Pubmed]
  16. Conservation of the MORF4 related gene family: identification of a new chromo domain subfamily and novel protein motif. Bertram, M.J., Pereira-Smith, O.M. Gene (2001) [Pubmed]
  17. Genetics of cellular senescence. Tominaga, K., Olgun, A., Smith, J.R., Pereira-Smith, O.M. Mech. Ageing Dev. (2002) [Pubmed]
  18. Neurons in Alzheimer disease emerge from senescence. Raina, A.K., Pardo, P., Rottkamp, C.A., Zhu, X., Pereira-Smith, O.M., Smith, M.A. Mech. Ageing Dev. (2001) [Pubmed]
  19. MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. Pardo, P.S., Leung, J.K., Lucchesi, J.C., Pereira-Smith, O.M. J. Biol. Chem. (2002) [Pubmed]
  20. The enhanced production of hyaluronic acid by cultured rat fibroblast cells treated with cyclic AMP and its dibutyryl derivative. Koyama, D., Tomida, M., Ono, T. J. Cell. Physiol. (1975) [Pubmed]
  21. Silent cerebral infarcts in sickle cell anemia: a risk factor analysis. The Cooperative Study of Sickle Cell Disease. Kinney, T.R., Sleeper, L.A., Wang, W.C., Zimmerman, R.A., Pegelow, C.H., Ohene-Frempong, K., Wethers, D.L., Bello, J.A., Vichinsky, E.P., Moser, F.G., Gallagher, D.M., DeBaun, M.R., Platt, O.S., Miller, S.T. Pediatrics (1999) [Pubmed]
  22. Functional analysis of MRG-1: the ortholog of human MRG15 in Caenorhabditis elegans. Olgun, A., Aleksenko, T., Pereira-Smith, O.M., Vassilatis, D.K. J. Gerontol. A Biol. Sci. Med. Sci. (2005) [Pubmed]
  23. alpha-enolase, a novel strong plasmin(ogen) binding protein on the surface of pathogenic streptococci. Pancholi, V., Fischetti, V.A. J. Biol. Chem. (1998) [Pubmed]
  24. Adrenal function in normal infants and in marasmus and kwashiorkor. Cortisol secretion, diurnal variation of plasma cortisol, and urinary excretion of 17-hydroxycorticoids, free corticoids, and cortisol. Beitins, I.Z., Kowarski, A., Migeon, C.J., Graham, G.G. J. Pediatr. (1975) [Pubmed]
  25. Bronchial inflammation in corticosteroid-sensitive and corticosteroid-resistant asthma at baseline and on oral corticosteroid treatment. Chakir, J., Hamid, Q., Bossé, M., Boulet, L.P., Laviolette, M. Clin. Exp. Allergy (2002) [Pubmed]
  26. The effect of the environment on the crack initiation toughness of dental poly(methyl methacrylate). Hargreaves, A.S. J. Biomed. Mater. Res. (1981) [Pubmed]
  27. MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. Tominaga, K., Leung, J.K., Rookard, P., Echigo, J., Smith, J.R., Pereira-Smith, O.M. J. Biol. Chem. (2003) [Pubmed]
  28. Cancer-associated loss of TARSH gene expression in human primary lung cancer. Terauchi, K., Shimada, J., Uekawa, N., Yaoi, T., Maruyama, M., Fushiki, S. J. Cancer Res. Clin. Oncol. (2006) [Pubmed]
  29. Common senescent cell-specific antibody epitopes on fibronectin in species and cells of varied origin. Porter, M.B., Pereira-Smith, O.M., Smith, J.R. J. Cell. Physiol. (1992) [Pubmed]
  30. A novel DNA virus (SEN) among patients on maintenance hemodialysis: prevalence and clinical importance. Schröter, M., Laufs, R., Zöllner, B., Knödler, B., Schäfer, P., Feucht, H.H. J. Clin. Virol. (2003) [Pubmed]
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