Disease relevance of MORF4

• We conclude that coinfection with SEN viruses is frequent in chronic hepatitis C patients and might adversely affect the outcome of treatment with interferon and ribavirin [1].
• SEN and sensibility: interactions between newly discovered and other hepatitis viruses [2]?
• Effect on treatment outcome of coinfection with SEN viruses in patients with hepatitis C [1].
• Independently, the Senegal (SEN) beta s haplotype has been found in association with elevated Hb F in SS and beta-thalassemia patients [3].
• SEN virus (SEN-V) is a recently identified single-stranded, circular DNA virus [4].

Psychiatry related information on MORF4

• METHODS: Polysomnograms with digitized video surveillance of 20 consecutive patients with heart failure and CSA-CSR were analyzed for total apnea-hypopnea index, mean event duration, and mean oxygen desaturation according to sleep stage and position [5].
• Specifically, presence of coexistent depression accounted for 17% of the variance in clinician severity ratings (CSR; P < .01), with individuals diagnosed with a comorbid mood disorder receiving higher clinician severity ratings [6].

High impact information on MORF4

• Genome-Wide Distribution of Yeast RNA Polymerase II and Its Control by Sen1 Helicase [7].
• Remarkably, a single amino acid substitution that compromises Sen1 function causes profound changes in Pol II distribution over both noncoding and protein-coding genes, establishing an important function of Sen1 in the regulation of transcription [7].
• We assessed whether coinfection of patients with chronic hepatitis C and SEN D or SEN H correlates with the outcome of treatment with interferon and ribavirin [1].
• Two AS cases carrying SEN had low Hb F and low F cells, while three AS and one CS carrying BEN had elevated Hb F and elevated F cells; only one AS carrying BEN had low Hb F and low F cells [3].
• We report the cloning and identification of a gene, mortality factor 4 (MORF 4), which induces a senescent-like phenotype in immortal cell lines assigned to complementation group B with concomitant changes in two markers for senescence [8].

Chemical compound and disease context of MORF4

• Isolation of a human intestinal anaerobe, Bifidobacterium sp. strain SEN, capable of hydrolyzing sennosides to sennidins [9].
• Comparisons were made between SEN V--positive and SEN V--negative groups in terms of age, time posttransplantation, indications for transplantation, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and cytomegalovirus and Epstein-Barr virus status [10].
• A possible approach to this problem is to search for CLCN5 mutations in patients who may have a high prevalence of mutations: end-stage renal disease (ESRD) patients with previous calcium, struvite, or radio-opaque (CSR) stones [11].
• A sennoside-hydrolyzing beta-glucosidase from Bifidobacterium sp. strain SEN is inducible [12].
• While potassium (K+) and hemoglobin leakage from RBC were the parameters used to evaluate the acute and chronic toxicity, respectively, the efficacy of AmB-LP and AmB-M were assessed by K+ leakage or cell survival rate (CSR) from Ct [13].

Biological context of MORF4

• More recently we have cloned the gene on chromosome 4, MORF 4 [14].
• There were no mutations or deletions, and two of the seven lines that showed loss of heterozygosity at 4q33-q34 were heterozygous for MORF4 itself [15].
• Conservation of the MORF4 related gene family: identification of a new chromo domain subfamily and novel protein motif [16].
• MORF4 was cloned as the senescence-related gene on human chromosome 4 and is a member of a new gene family, which has multiple transcription factor-like motifs [17].
• Our results show that many neurons in vulnerable regions of Alzheimer disease brain, but not in control brain, have increased MORF4-related proteins indicating re-entry into the cell cycle [18].

Anatomical context of MORF4

• These results suggest that the inactivation of MORF4 is not required for human keratinocyte immortality [15].
• MORF4 (mortality factor on chromosome 4) induces senescence in a subset of human tumor cell lines [19].
• Cells of a newly established rat fibroblast line (SEN) in culture synthesize mucopolysaccharides, which have been identified as hyaluronic acid, chondroitin-4-sulfate and heparan sulfate [20].
• A strictly anaerobic bacterium capable of metabolizing sennosides was isolated from human feces and identified as Bifidobacterium sp., named strain SEN [9].
• Lower hemoglobin level, increased leukocyte count, elevated pocked red blood cell count, and SEN betaS globin gene haplotype were associated also with the presence of silent infarcts [21].

Associations of MORF4 with chemical compounds

• Mortality Factor on Chromosome 4 (MORF4) induces senescence in several immortal human cell lines [22].
• Both the C-terminal lysine residue of SEN and a region N-terminal to it play a critical role in plasminogen binding [23].
• CSR and 17OHCS excretions were not different from age controls, but were significantly lower than size controls, THF/THE ratios, urinary excretion of free corticoids and cortisol were normal [24].
• Oral CS decreased CD3+ cell counts (medians: 60-20 cells/mm(2); P = 0.014) and MBP+ cell counts (medians: 19-4 cells/mm(2); P = 0.03) in CSS asthmatics, but only tryptase+ cell counts in CSR asthmatics (medians: 30-18 cells/mm(2); P = 0.05) [25].
• In the light of this, SEN specimens of heat-cured denture-base PMMA were saturated in a range of liquids and extended to failure at chewing speed [26].

Other interactions of MORF4

• MRG15 is a novel chromodomain protein that is a member of a family of genes related to MORF4 [19].
• MRGX is a novel transcription factor that is a member of the mortality factor 4 (MORF4)-related gene family [27].
• PURPOSE: We have previously identified mouse Tarsh as one of the cellular senescence-related genes and showed the loss of expression of TARSH mRNA in four human lung cancer cell lines [28].

Analytical, diagnostic and therapeutic context of MORF4

• Overall response (RNA titre and alanine aminotransferase concentration after treatment) was lower in SEN-infected patients than uninfected patients (p=0.025) [1].
• Fibronectin from 11 additional species was also analyzed by Western immunoblot for ability to bind the SEN antibodies [29].
• We conclude that SEN V is common among liver transplant recipients but does not appear to cause graft dysfunction as an isolated agent [10].
• A cross-sectional study of SEN virus in liver transplant recipients [10].
• Until now, it is unclear whether patients on maintenance hemodialysis are on increased risk for acquiring SEN virus [30].

References