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Gene Review:

BZW1 - basic leucine zipper and W2 domains 1

Homo sapiens

Synonyms: BZAP45, Basic leucine zipper and W2 domain-containing protein 1, KIAA0005, Nbla10236, Protein Orf

Mitra, P. et al.

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High impact information on BZW1

Deletion analyses and point mutations indicate that BZAP45 enhances H4 gene transcription through Site II [1].
Thus, BZAP45 is a novel regulatory factor that contributes to transcriptional control at the G1/S phase transition [1].
Based on amino acid sequence analysis, BZAP45 contains a unique decapeptide that is part of a putative leucine-zipper protein with a nucleotide (ATP or GTP) binding fold [1].

Biological context of BZW1

Forced expression of BZAP45 strongly stimulates H4 promoter (nt -215 to -1)/CAT reporter gene activity [1].

Analytical, diagnostic and therapeutic context of BZW1

Using sequence-specific Site II DNA affinity chromatography, we identified a 45 kDa protein (KIAA0005 or BZAP45) that is embryonically expressed and phylogenetically conserved [1].

References

Purification and functional analysis of a novel leucine-zipper/nucleotide-fold protein, BZAP45, stimulating cell cycle regulated histone H4 gene transcription. Mitra, P., Vaughan, P.S., Stein, J.L., Stein, G.S., van Wijnen, A.J. Biochemistry (2001) [Pubmed]

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