Gene Review:
DDAH2 - dimethylarginine dimethylaminohydrolase 2
Homo sapiens
Synonyms:
DDAH, DDAH-2, DDAHII, Dimethylargininase-2, Dimethylarginine dimethylaminohydrolase 2, ...
- Haplotypic association of DDAH1 with susceptibility to pre-eclampsia. Akbar, F., Heinonen, S., Pirskanen, M., Uimari, P., Tuomainen, T.P., Salonen, J.T. Mol. Hum. Reprod. (2005)
- Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension. Pullamsetti, S., Kiss, L., Ghofrani, H.A., Voswinckel, R., Haredza, P., Klepetko, W., Aigner, C., Fink, L., Muyal, J.P., Weissmann, N., Grimminger, F., Seeger, W., Schermuly, R.T. FASEB J. (2005)
- beta-Catenin Overexpression Reduces Myocardial Infarct Size through Differential Effects on Cardiomyocytes and Cardiac Fibroblasts. Hahn, J.Y., Cho, H.J., Bae, J.W., Yuk, H.S., Kim, K.I., Park, K.W., Koo, B.K., Chae, I.H., Shin, C.S., Oh, B.H., Choi, Y.S., Park, Y.B., Kim, H.S. J. Biol. Chem. (2006)
- Molecular mechanism for elevation of asymmetric dimethylarginine and its role for hypertension in chronic kidney disease. Matsuguma, K., Ueda, S., Yamagishi, S., Matsumoto, Y., Kaneyuki, U., Shibata, R., Fujimura, T., Matsuoka, H., Kimoto, M., Kato, S., Imaizumi, T., Okuda, S. J. Am. Soc. Nephrol. (2006)
- Characterization of a transient covalent adduct formed during dimethylarginine dimethylaminohydrolase catalysis. Stone, E.M., Person, M.D., Costello, N.J., Fast, W. Biochemistry (2005)
- Common genetic variation in a basal promoter element alters DDAH2 expression in endothelial cells. Jones, L.C., Tran, C.T., Leiper, J.M., Hingorani, A.D., Vallance, P. Biochem. Biophys. Res. Commun. (2003)
- Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Ericson, J., Morton, S., Kawakami, A., Roelink, H., Jessell, T.M. Cell (1996)
- Leukocytosis and natural killer cell function parallel neurobehavioral fatigue induced by 64 hours of sleep deprivation. Dinges, D.F., Douglas, S.D., Zaugg, L., Campbell, D.E., McMann, J.M., Whitehouse, W.G., Orne, E.C., Kapoor, S.C., Icaza, E., Orne, M.T. J. Clin. Invest. (1994)
- Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Liu, J., Puscheck, E.E., Wang, F., Trostinskaia, A., Barisic, D., Maniere, G., Wygle, D., Zhong, W., Rings, E.H., Rappolee, D.A. Reproduction (2004)
- Immunopharmacology of rapamycin. Abraham, R.T., Wiederrecht, G.J. Annu. Rev. Immunol. (1996)
- Re-Evaluating Cell-Cycle Regulation by E2Fs. Rowland, B.D., Bernards, R. Cell (2006)
- Wapl controls the dynamic association of cohesin with chromatin. Kueng, S., Hegemann, B., Peters, B.H., Lipp, J.J., Schleiffer, A., Mechtler, K., Peters, J.M. Cell (2006)
- A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint. Rohaly, G., Chemnitz, J., Dehde, S., Nunez, A.M., Heukeshoven, J., Deppert, W., Dornreiter, I. Cell (2005)
- CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Mailand, N., Diffley, J.F. Cell (2005)
- Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase. Stone, E.M., Schaller, T.H., Bianchi, H., Person, M.D., Fast, W. Biochemistry (2005)
- Prediction of relapse or survival in patients with node-negative breast cancer by DNA flow cytometry. Clark, G.M., Dressler, L.G., Owens, M.A., Pounds, G., Oldaker, T., McGuire, W.L. N. Engl. J. Med. (1989)
- A novel chromosome abnormality in human neuroblastoma and antifolate-resistant Chinese hamster cell lives in culture. Biedler, J.L., Spengler, B.A. J. Natl. Cancer Inst. (1976)
- Selective killing of oncogenic human cells cocultivated with normal human fibroblasts. Warrington, R.C. J. Natl. Cancer Inst. (1978)
- Tyrosine aminotransferase sensitivity to bromodeoxyuridine during restricted intervals of S phase in hepatoma cells. O'Brien, J.C. J. Cell Biol. (1980)
- Dimethylarginine dimethylaminohydrolase-2 overexpression improves impaired nitric oxide synthesis of endothelial cells induced by glycated protein. Lu, C.W., Xiong, Y., He, P. Nitric Oxide (2007)
- Dimethylarginine dimethylaminohydrolase 2 increases vascular endothelial growth factor expression through Sp1 transcription factor in endothelial cells. Hasegawa, K., Wakino, S., Tanaka, T., Kimoto, M., Tatematsu, S., Kanda, T., Yoshioka, K., Homma, K., Sugano, N., Kurabayashi, M., Saruta, T., Hayashi, K. Arterioscler. Thromb. Vasc. Biol. (2006)
- Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary origins. Tran, C.T., Fox, M.F., Vallance, P., Leiper, J.M. Genomics (2000)
- Dimethylarginine dimethylaminohydrolase and endothelial dysfunction in failing hearts. Chen, Y., Li, Y., Zhang, P., Traverse, J.H., Hou, M., Xu, X., Kimoto, M., Bache, R.J. Am. J. Physiol. Heart Circ. Physiol. (2005)
- Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype. Smith, C.L., Birdsey, G.M., Anthony, S., Arrigoni, F.I., Leiper, J.M., Vallance, P. Biochem. Biophys. Res. Commun. (2003)
- S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase. Leiper, J., Murray-Rust, J., McDonald, N., Vallance, P. Proc. Natl. Acad. Sci. U.S.A. (2002)
- ADMA: a novel risk factor that explains excess cardiovascular event rate in patients with end-stage renal disease. Böger, R.H., Zoccali, C. Atherosclerosis. Supplements. (2003)
- Erythropoietin increases asymmetric dimethylarginine in endothelial cells: role of dimethylarginine dimethylaminohydrolase. Scalera, F., Kielstein, J.T., Martens-Lobenhoffer, J., Postel, S.C., Täger, M., Bode-Böger, S.M. J. Am. Soc. Nephrol. (2005)
- S-phase arrest and apoptosis induced in normal mammary epithelial cells by a novel retinoid. Zhang, Y., Rishi, A.K., Dawson, M.I., Tschang, R., Farhana, L., Boyanapalli, M., Reichert, U., Shroot, B., Van Buren, E.C., Fontana, J.A. Cancer Res. (2000)
- Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners. Frouin, I., Maga, G., Denegri, M., Riva, F., Savio, M., Spadari, S., Prosperi, E., Scovassi, A.I. J. Biol. Chem. (2003)
- Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site. Li, J.M., Nichols, M.A., Chandrasekharan, S., Xiong, Y., Wang, X.F. J. Biol. Chem. (1995)
- pRb2/p130 and p107 control cell growth by multiple strategies and in association with different compartments within the nucleus. Zini, N., Trimarchi, C., Claudio, P.P., Stiegler, P., Marinelli, F., Maltarello, M.C., La Sala, D., De Falco, G., Russo, G., Ammirati, G., Maraldi, N.M., Giordano, A., Cinti, C. J. Cell. Physiol. (2001)
- The MDM2 RING finger is required for cell cycle-dependent regulation of its protein expression. Gu, L., Ying, H., Zheng, H., Murray, S.A., Xiao, Z.X. FEBS Lett. (2003)
- Hyperphosphorylation of replication protein A middle subunit (RPA32) in apoptosis. Treuner, K., Okuyama, A., Knippers, R., Fackelmayer, F.O. Nucleic Acids Res. (1999)
- Dual mode of degradation of Cdc25 A phosphatase. Donzelli, M., Squatrito, M., Ganoth, D., Hershko, A., Pagano, M., Draetta, G.F. EMBO J. (2002)
- Cdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A. Alexandrow, M.G., Hamlin, J.L. Mol. Cell. Biol. (2004)
- Skp2 induction and phosphorylation is associated with the late G1 phase of proliferating rat hepatocytes. Bilodeau, M., Talarmin, H., Ilyin, G., Rescan, C., Glaise, D., Cariou, S., Loyer, P., Guguen-Guillouzo, C., Baffet, G. FEBS Lett. (1999)
- Identification and characterization of a human protein kinase related to budding yeast Cdc7p. Jiang, W., Hunter, T. Proc. Natl. Acad. Sci. U.S.A. (1997)
- DNA damage-induced accumulation of Rad18 protein at stalled replication forks in mammalian cells involves upstream protein phosphorylation. Nikiforov, A., Svetlova, M., Solovjeva, L., Sasina, L., Siino, J., Nazarov, I., Bradbury, M., Tomilin, N. Biochem. Biophys. Res. Commun. (2004)
- E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Leone, G., DeGregori, J., Yan, Z., Jakoi, L., Ishida, S., Williams, R.S., Nevins, J.R. Genes Dev. (1998)
- The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase. Baeg, G.H., Matsumine, A., Kuroda, T., Bhattacharjee, R.N., Miyashiro, I., Toyoshima, K., Akiyama, T. EMBO J. (1995)
- The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis. Brown, D.R., Thomas, C.A., Deb, S.P. EMBO J. (1998)
- G1 phase arrest induced by Wilms tumor protein WT1 is abrogated by cyclin/CDK complexes. Kudoh, T., Ishidate, T., Moriyama, M., Toyoshima, K., Akiyama, T. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression. Lukas, J., Petersen, B.O., Holm, K., Bartek, J., Helin, K. Mol. Cell. Biol. (1996)
- Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region. Ribas, G., Neville, M., Wixon, J.L., Cheng, J., Campbell, R.D. J. Immunol. (1999)
- Phosphorylation of MCM4 by Cdc7 Kinase Facilitates Its Interaction with Cdc45 on the Chromatin. Masai, H., Taniyama, C., Ogino, K., Matsui, E., Kakusho, N., Matsumoto, S., Kim, J.M., Ishii, A., Tanaka, T., Kobayashi, T., Tamai, K., Ohtani, K., Arai, K. J. Biol. Chem. (2006)
- Probucol decreases asymmetrical dimethylarginine level by alternation of protein arginine methyltransferase I and dimethylarginine dimethylaminohydrolase activity. Jiang, J.L., Zhang, X.H., Li, N.S., Rang, W.Q., Feng-Ye, n.u.l.l., Hu, C.P., Li, Y.J., Deng, H.W. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy (2006)
- Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease. Tanaka, M., Sydow, K., Gunawan, F., Jacobi, J., Tsao, P.S., Robbins, R.C., Cooke, J.P. Circulation (2005)
- An enzyme hydrolyzing methylated inhibitors of nitric oxide synthase is present in circulating human red blood cells. Kang, E.S., Cates, T.B., Harper, D.N., Chiang, T.M., Myers, L.K., Acchiardo, S.R., Kimoto, M. Free Radic. Res. (2001)