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Gene Review

CROCC  -  ciliary rootlet coiled-coil, rootletin

Homo sapiens

Synonyms: Ciliary rootlet coiled-coil protein, KIAA0445, ROLT, Rootletin, rootletin
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High impact information on CROCC


Anatomical context of CROCC

  • Recombinant rootletin forms detergent-insoluble filaments radiating from the centrioles and resembling rootlets found in vivo [2].

Other interactions of CROCC

  • Whereas the overexpression of rootletin results in the formation of extensive fibers, small interfering RNA-mediated depletion of either rootletin or C-Nap1 causes centrosome splitting, suggesting that both proteins contribute to maintaining centrosome cohesion [1].


  1. Rootletin forms centriole-associated filaments and functions in centrosome cohesion. Bahe, S., Stierhof, Y.D., Wilkinson, C.J., Leiss, F., Nigg, E.A. J. Cell Biol. (2005) [Pubmed]
  2. Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet. Yang, J., Liu, X., Yue, G., Adamian, M., Bulgakov, O., Li, T. J. Cell Biol. (2002) [Pubmed]
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