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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DHX38  -  DEAH (Asp-Glu-Ala-His) box polypeptide 38

Homo sapiens

Synonyms: ATP-dependent RNA helicase DHX38, DDX38, DEAH box protein 38, KIAA0224, PRP16, ...
 
 
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High impact information on DHX38

  • PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome [1].
 

Analytical, diagnostic and therapeutic context of DHX38

  • Immunofluorescence microscopy studies demonstrated that hPrp16p co-localizes with snRNPs in subnuclear structures referred to as speckles [2].

References

  1. PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome. Schwer, B., Guthrie, C. Nature (1991) [Pubmed]
  2. The mammalian homologue of Prp16p is overexpressed in a cell line tolerant to Leflunomide, a new immunoregulatory drug effective against rheumatoid arthritis. Ortlepp, D., Laggerbauer, B., Müllner, S., Achsel, T., Kirschbaum, B., Lührmann, R. RNA (1998) [Pubmed]
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