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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CEP350  -  centrosomal protein 350kDa

Homo sapiens

Synonyms: CAP350, Centrosome-associated protein 350, Centrosome-associated protein of 350 kDa, Cep350, GM133, ...
 
 
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High impact information on CEP350

  • We show that the C-terminal domain of CAP350 interacts directly with FOP and that both proteins localize to the centrosome throughout the cell cycle [1].
  • These results have implications for the mechanisms underlying MT anchoring at the centrosome and they attribute a key MT anchoring function to two novel centrosomal proteins, CAP350 and FOP [1].
  • CAP350 inhibited PPAR(alpha)-mediated transactivation in an LXXLL-dependent manner, suggesting that CAP350 represses PPAR(alpha) function [2].
  • However, in the presence of coexpressed CAP350, PPAR(alpha) colocalizes with CAP350 to discrete nuclear foci and to the centrosome, perinuclear region and intermediate filaments [2].
  • CAP350 also interacts with PPAR(delta), PPAR(gamma) and liver-X-receptor alpha, but not with the 9-cis retinoic acid receptor, RXR(alpha) [2].
 

Anatomical context of CEP350

References

  1. A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. Yan, X., Habedanck, R., Nigg, E.A. Mol. Biol. Cell (2006) [Pubmed]
  2. Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350. Patel, H., Truant, R., Rachubinski, R.A., Capone, J.P. J. Cell. Sci. (2005) [Pubmed]
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