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Chemical Compound Review

Panretin     (2E,4E,6Z,8E)-3,7-dimethyl-9- (2,6,6...

Synonyms: Panretyn, Panrexin, Toctino, Alitretinoin, alitretinoina, ...
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Disease relevance of AIDS-060996


High impact information on AIDS-060996

  • In vitro, LGD346 suppressed the activity of the thyrotropin beta-subunit gene promoter in thyrotrophs by as much as 50 percent, an effect similar to that of triiodothyronine and 9-cis-retinoic acid [6].
  • The 9-cis retinoic acid receptor (RXR) serves as a common heterodimerization partner for several nuclear receptors, including the thyroid hormone receptor (T3R) and retinoic acid receptor (RAR) [7].
  • Using all-trans and 9-cis RA, which differentially activate RARs and RXRs, and RAR and RXR dominant-negative mutants, RAR-RXR heterodimers bound to RARE1 and RARE2 are shown to be responsible for CRABPII promoter transactivation, arguing against a unique DR spacing specifying recognition by RARs [8].
  • In contrast, all-trans and 9-cis RA have identical effects on induction of RAR beta 2 transcripts [8].
  • Consistent with these results, 9-cis RA increases CRABPII mRNA levels more efficiently than all-trans RA [8].

Chemical compound and disease context of AIDS-060996


Biological context of AIDS-060996


Anatomical context of AIDS-060996


Associations of AIDS-060996 with other chemical compounds


Gene context of AIDS-060996


Analytical, diagnostic and therapeutic context of AIDS-060996


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