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Gene Review

hly  -  listeriolysin O precursor

Listeria monocytogenes EGD-e

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Disease relevance of hly

  • Methods for curing endogenous prophages from the comK attachment site in 10403S-derived strains were developed. pPL1 was used to introduce the hly and actA genes at comK-attBB' in deletion strains derived from 10403S and SLCC-5764 [1].

High impact information on hly

  • Specific binding of PrfA-containing extracts from strain EGD to the hly and actA promoter sequences was strongly inhibited by iron, whereas that of extracts from strain NCTC 7973 was only slightly reduced [2].


  1. Construction, characterization, and use of two Listeria monocytogenes site-specific phage integration vectors. Lauer, P., Chow, M.Y., Loessner, M.J., Portnoy, D.A., Calendar, R. J. Bacteriol. (2002) [Pubmed]
  2. Specific binding of the Listeria monocytogenes transcriptional regulator PrfA to target sequences requires additional factor(s) and is influenced by iron. Böckmann, R., Dickneite, C., Middendorf, B., Goebel, W., Sokolovic, Z. Mol. Microbiol. (1996) [Pubmed]
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