Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

actA - actin-assembly inducing protein precursor

Listeria monocytogenes EGD-e

Nightingale, K.K. et al., Lauer, P. et al., Le Monnier, A. et al., Jiang, L. et al., Virna, S. et al.

Nightingale, Lyles, Ayodele, Jalan, Nielsen, Wiedmann,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of actA

Methods for curing endogenous prophages from the comK attachment site in 10403S-derived strains were developed. pPL1 was used to introduce the hly and actA genes at comK-attBB' in deletion strains derived from 10403S and SLCC-5764 [1].
Listeria monocytogenes Mutants Carrying Newcastle Disease Virus F Gene Fused to its actA and plcB: In vitro Expression and Immunogenicity in Chickens [2].

High impact information on actA

Upon infection with actA-deficient LM, macrophages and microglial cells rapidly, and later LM-specific CD4 and CD8 T cells, produced TNF [3].
Definitive evidence for the role of ActA was provided by showing that a actA-complemented DeltaActA mutant was restored in its capacity to invade fetuses [4].
Analysis of sequence data for 120 L. monocytogenes isolates revealed evidence of clustering between isolates from the same source, based on the phylogenies inferred from actA and inlA (P = 0.02 and P = 0.07, respectively; SourceCluster test) [5].

References

Construction, characterization, and use of two Listeria monocytogenes site-specific phage integration vectors. Lauer, P., Chow, M.Y., Loessner, M.J., Portnoy, D.A., Calendar, R. J. Bacteriol. (2002) [Pubmed]
Listeria monocytogenes Mutants Carrying Newcastle Disease Virus F Gene Fused to its actA and plcB: In vitro Expression and Immunogenicity in Chickens. Jiang, L., Ke, C., Xu, J., Chen, J., Chen, X., Chen, N., Shuai, J., Fang, W. Acta Biochim. Biophys. Sin. (Shanghai) (2007) [Pubmed]
TNF Is Important for Pathogen Control and Limits Brain Damage in Murine Cerebral Listeriosis. Virna, S., Deckert, M., Lütjen, S., Soltek, S., Foulds, K.E., Shen, H., Körner, H., Sedgwick, J.D., Schlüter, D. J. Immunol. (2006) [Pubmed]
ActA is required for crossing of the fetoplacental barrier by Listeria monocytogenes. Le Monnier, A., Autret, N., Join-Lambert, O.F., Jaubert, F., Charbit, A., Berche, P., Kayal, S. Infect. Immun. (2007) [Pubmed]
Novel Method To Identify Source-Associated Phylogenetic Clustering Shows that Listeria monocytogenes Includes Niche-Adapted Clonal Groups with Distinct Ecological Preferences. Nightingale, K.K., Lyles, K., Ayodele, M., Jalan, P., Nielsen, R., Wiedmann, M. J. Clin. Microbiol. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.