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MeSH Review:

Orthoreovirus

Zhang, Y. et al., Broering, T.J. et al., Attoui, H. et al.

Zhang, Liu, Hu, Ouyang, Tong,

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Disease relevance of Orthoreovirus

The His and Cys residues are part of a small consensus motif that is conserved across muNS homologs from avian orthoreoviruses and aquareoviruses, suggesting this motif may have a common function in these related viruses [1].

High impact information on Orthoreovirus

Comparison with Reoviridae proteins showed significant similarities to RDRPs (CTFV-VP1) and sigma C protein of orthoreovirus (CTFV-VP6) [2].
The degree of differences between the S14/C4 and ARV was only 23-24%, and 21-22%, respectively, at both the nucleotide and deduced amino acid levels, suggested that DRVs are quite different from ARVs and should give a precise classification for DRVs in Orthoreovirus genus [3].

References

Carboxyl-proximal regions of reovirus nonstructural protein muNS necessary and sufficient for forming factory-like inclusions. Broering, T.J., Arnold, M.M., Miller, C.L., Hurt, J.A., Joyce, P.L., Nibert, M.L. J. Virol. (2005) [Pubmed]
Sequence determination and analysis of the full-length genome of colorado tick fever virus, the type species of genus Coltivirus (Family Reoviridae). Attoui, H., Billoir, F., Biagini, P., Cantaloube, J.F., de Chesse, R., de Micco, P., de Lamballerie, X. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
Characterization of the sigmaC-encoding Gene from Musocvy Duck Reovirus. Zhang, Y., Liu, M., Hu, Q., Ouyang, S., Tong, G. Virus Genes (2006) [Pubmed]

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