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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Reoviridae

  • The 7-methylguanylic acid residue confronting the 5'-terminal nucleotide of mRNA through two pyrophosphate linkages was completely removed by tobacco pyrophosphatase from mRNAs of cytoplasmic polyhedrosis virus, tobacco mosaic virus (viral RNA), and globin without any scission in the inner part of the RNA chain [1].
  • The outer capsid layer of Bluetongue virus, a member of the nonenveloped Reoviridae family, is composed of two proteins, a receptor-binding protein, VP2, and a second protein, VP5, which shares structural features with class I fusion proteins of enveloped viruses [2].
  • The role of NSP3 in rotavirus replication is discussed in the light of our results and by comparison with other RNA-binding proteins of members of the Reoviridae family [3].
  • A first full outer capsid protein sequence data-set in the Orbivirus genus (family Reoviridae): cloning, sequencing, expression and analysis of a complete set of full-length outer capsid VP2 genes of the nine African horsesickness virus serotypes [4].
  • The segment encodes a putative protein of 40 kDa that exhibits approximately 37% homology at the amino acid level to the nonstructural proteins Pns10 of rice dwarf and wound tumor viruses, which are other members of Phytoreovirus [5].

High impact information on Reoviridae


Chemical compound and disease context of Reoviridae

  • Particles that were purified on caesium chloride gradients had a mean size of 75 nm (a size similar to the size of intact particles of members of the family Reoviridae), indicating that they lost outer-coat components [10].
  • The 3' tetranucleotides of the plus strand of all genome segments of RDV and RGDV were found to be the same (---UGAU 3'), except for segment 9 of RDV which had the 3'-terminal sequence---CGAU 3'. The conserved 3'-terminal sequence (---UGAU 3') was the same as that found in the genome segments of WTV, another member of the Phytoreovirus genus [11].
  • A large-scale mortality of larval and juvenile halibut Hippoglossus hippoglossus occurred at a semi-commercial halibut farm in Atlantic Canada. Investigation of the cause revealed aquareovirus particles in necrotic liver tissue of affected fish [12].
  • Nucleoside triphosphate phosphohydrolase associated with cytoplasmic polyhedrosis virus [13].
  • Lipofectin increases the specific activity of cypovirus particles for cultured insect cells [14].

Biological context of Reoviridae


Anatomical context of Reoviridae


Gene context of Reoviridae


Analytical, diagnostic and therapeutic context of Reoviridae


  1. Importance of 5'-terminal blocking structure to stabilize mRNA in eukaryotic protein synthesis. Shimotohno, K., Kodama, Y., Hashimoto, J., Miura, K.I. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  2. A capsid protein of nonenveloped Bluetongue virus exhibits membrane fusion activity. Forzan, M., Wirblich, C., Roy, P. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Rotavirus protein NSP3 (NS34) is bound to the 3' end consensus sequence of viral mRNAs in infected cells. Poncet, D., Aponte, C., Cohen, J. J. Virol. (1993) [Pubmed]
  4. A first full outer capsid protein sequence data-set in the Orbivirus genus (family Reoviridae): cloning, sequencing, expression and analysis of a complete set of full-length outer capsid VP2 genes of the nine African horsesickness virus serotypes. Potgieter, A.C., Cloete, M., Pretorius, P.J., van Dijk, A.A. J. Gen. Virol. (2003) [Pubmed]
  5. Sequence analysis of Pns11, a nonstructural protein of rice gall dwarf virus, and its expression and detection in infected rice plants and vector insects. Moriyasu, Y., Ishikawa, K., Kikuchi, A., Imanishi, S., Tomita, S., Akutsu, K., Omura, T. Virus Genes (2000) [Pubmed]
  6. Allosteric stimulatory effect of S-adenosylmethionine on the RNA polymerase in cytoplasmic polyhedrosis virus. A model for the positive control of eukaryotic transcription. Furuichi, Y. J. Biol. Chem. (1981) [Pubmed]
  7. Rice dwarf phytoreovirus segment S6-encoded nonstructural protein has a cell-to-cell movement function. Li, Y., Bao, Y.M., Wei, C.H., Kang, Z.S., Zhong, Y.W., Mao, P., Wu, G., Chen, Z.L., Schiemann, J., Nelson, R.S. J. Virol. (2004) [Pubmed]
  8. Identification and characterization of the helix-destabilizing activity of rotavirus nonstructural protein NSP2. Taraporewala, Z.F., Patton, J.T. J. Virol. (2001) [Pubmed]
  9. S-adenosyl-L-homocysteine as a stimulator of viral RNA synthesis by two distinct cytoplasmic polyhedrosis viruses. Mertens, P.P., Payne, C.C. J. Virol. (1978) [Pubmed]
  10. Micromonas pusilla reovirus: a new member of the family Reoviridae assigned to a novel proposed genus (Mimoreovirus). Attoui, H., Jaafar, F.M., Belhouchet, M., de Micco, P., de Lamballerie, X., Brussaard, C.P. J. Gen. Virol. (2006) [Pubmed]
  11. Viruses in the phytoreovirus genus of the Reoviridae family have the same conserved terminal sequences. Kudo, H., Uyeda, I., Shikata, E. J. Gen. Virol. (1991) [Pubmed]
  12. Pathology associated with an aquareovirus in captive juvenile Atlantic halibut Hippoglossus hippoglossus and an experimental treatment strategy for a concurrent bacterial infection. Cusack, R.R., Groman, D.B., MacKinnon, A.M., Kibenge, F.S., Wadowska, D., Brown, N. Dis. Aquat. Org. (2001) [Pubmed]
  13. Nucleoside triphosphate phosphohydrolase associated with cytoplasmic polyhedrosis virus. Shimotohno, K., Miura, K. J. Biochem. (1977) [Pubmed]
  14. Lipofectin increases the specific activity of cypovirus particles for cultured insect cells. Hill, C.L., Booth, T.F., Stuart, D.I., Mertens, P.P. J. Virol. Methods (1999) [Pubmed]
  15. S-Adenosylmethionine and its analogs. Structural features correlated with synthesis and methylation of mRNAs of cytoplasmic polyhedrosis virus. Wertheimer, A.M., Chen, S.Y., Borchardt, R.T., Furuichi, Y. J. Biol. Chem. (1980) [Pubmed]
  16. Genomic sequence analyses of segments 1 to 6 of Dendrolimus punctatus cytoplasmic polyhedrosis virus. Zhao, S.L., Liang, C.Y., Hong, J.J., Peng, H.Y. Arch. Virol. (2003) [Pubmed]
  17. In vivo and in vitro phosphorylation of rice dwarf phytoreovirus Pns12 cytoplasmic nonstructural protein. Suzuki, N., Hosokawa, D., Matsuura, Y., Kikuchi, A., Omura, T. Arch. Virol. (1999) [Pubmed]
  18. Inhibitory effect of methylated derivatives of guanylic acid for protein synthesis with reference to the functional structure of the 5'-'cap' in viral messenger RNA. Miura, K.I., Kodama, Y., Shimotohna, K., Fukui, T., Ikehara, M., Nakagawa, I., Hata, T. Biochim. Biophys. Acta (1979) [Pubmed]
  19. Molecular analysis of rice dwarf phytoreovirus segment S1: interviral homology of the putative RNA-dependent RNA polymerase between plant- and animal-infecting reoviruses. Suzuki, N., Tanimura, M., Watanabe, Y., Kusano, T., Kitagawa, Y., Suda, N., Kudo, H., Uyeda, I., Shikata, E. Virology (1992) [Pubmed]
  20. Multimers of the bluetongue virus nonstructural protein, NS2, possess nucleotidyl phosphatase activity: similarities between NS2 and rotavirus NSP2. Taraporewala, Z.F., Chen, D., Patton, J.T. Virology (2001) [Pubmed]
  21. Rice ragged stunt oryzavirus genome segment S4 could encode an RNA dependent RNA polymerase and a second protein of unknown function. Upadhyaya, N.M., Ramm, K., Gellatly, J.A., Li, Z., Kositratana, W., Waterhouse, P.M. Arch. Virol. (1998) [Pubmed]
  22. Rice ragged stunt oryzavirus genome segments S7 and S10 encode non-structural proteins of M(r) 68,025 (Pns7) and M(r) 32,364 (Pns10). Upadhyaya, N.M., Ramm, K., Gellatly, J.A., Li, Z., Kositratana, W., Waterhouse, P.M. Arch. Virol. (1997) [Pubmed]
  23. Sequence analysis and expression of the polyhedrin gene of Choristoneura fumiferana cytoplasmic polyhedrosis virus (CfCPV). Echeverry, F., Bergeron, J., Kaupp, W., Guertin, C., Arella, M. Gene (1997) [Pubmed]
  24. Effect of protectants in L-drying on the conformation and infectivity of rice dwarf phytoreovirus. Fukumoto, F., Omura, T., Kimura, I. Arch. Virol. (1996) [Pubmed]
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