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MeSH Review:

Neuroectodermal Tumor, Melanotic

Barrett, A.W. et al., de Souza, P.E. et al., Metwaly, H. et al., Nozicka, Z. et al.

Barrett, Morgan, Ramsay, Farthing, Newman, Speight,

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High impact information on Neuroectodermal Tumor, Melanotic

Melanotic neuroectodermal tumor of infancy with highly differentiated neural component. Light and electron microscopic study [1].
Three cell systems (MINT1/2/3) derived from a melanotic neuroectodermal tumor of infancy (MNTI) arising in the mandible of a 1-month-old newborn boy have been established, and their cytological natures have been characterized [2].
OBJECTIVE: The purpose of this study was to review the features of 8 cases of melanotic neuroectodermal tumor of infancy (MNTI) of the jaws with respect to the expression of NB84, CD99, PGP 9.5, specific cytokeratins, and Ki-67, markers not previously reported in this entity [3].
CONCLUSIONS: These data suggest that MDM-2 expression may be important for the development of melanotic neuroectodermal tumor of infancy and that the melanocytic cell population, not the neuroblastic one, is the proliferative component of the tumor [4].

References

Melanotic neuroectodermal tumor of infancy with highly differentiated neural component. Light and electron microscopic study. Nozicka, Z., Spacek, J. Acta Neuropathol. (1978) [Pubmed]
Establishment and characterization of new cell lines derived from melanotic neuroectodermal tumor of infancy arising in the mandible. Metwaly, H., Cheng, J., Maruyama, S., Ohshiro, K., Suzuki, I., Hoshina, Y., Saku, T. Pathol. Int. (2005) [Pubmed]
A clinicopathologic and immunohistochemical analysis of melanotic neuroectodermal tumor of infancy. Barrett, A.W., Morgan, M., Ramsay, A.D., Farthing, P.M., Newman, L., Speight, P.M. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2002) [Pubmed]
Cell cycle-associated proteins in melanotic neuroectodermal tumor of infancy. de Souza, P.E., Merly, F., Maia, D.M., Castro, W.H., Gomez, R.S. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (1999) [Pubmed]

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