Gene Review:
MKI67 - marker of proliferation Ki-67
Homo sapiens
Synonyms:
Antigen KI-67, KIA, MIB-, MIB-1, PPP1R105
Jain,
Li,
Yang,
Minoo,
Felix,
Chang,
Powles,
Allred,
Ashley,
Clark,
Makris,
Assersohn,
Gregory,
Osborne,
Dowsett,
Singletary,
Atkinson,
Hoque,
Sneige,
Sahin,
Fritsche,
Lotan,
Lu,
Hittelman,
Bevers,
Stelling,
Lippman,
Scholzen,
Endl,
Wohlenberg,
van der Sar,
Cowell,
Gerdes,
Singh,
Oreskovic,
Babic,
Kalafatic,
Barisic,
Beketic-Oreskovic,
Sereti,
Anthony,
Martinez-Wilson,
Lempicki,
Adelsberger,
Metcalf,
Hallahan,
Follmann,
Davey,
Kovacs,
Lane,
Spinillo,
Zara,
Zappatore,
Cesari,
Bergante,
Morbini,
Nagy,
Esiri,
Smith,
Rouanet,
Linares-Cruz,
Dravet,
Poujol,
Gourgou,
Simony-Lafontaine,
Grenier,
Kramar,
Girault,
Le Nestour,
Maudelonde,
Bubán,
Schmidt,
Broll,
Antal-Szalmás,
Duchrow,
Clarke,
Howell,
Potten,
Anderson,
Choi,
Pinto,
Ellis,
Coop,
Singh,
Tao,
Llombart-Cussac,
Jänicke,
Mauriac,
Quebe-Fehling,
Chaudri-Ross,
Evans,
Miller,
Joensuu,
Isola,
Lundin,
Salminen,
Holli,
Kataja,
Pylkkänen,
Turpeenniemi-Hujanen,
von Smitten,
Lundin,
- p53 protein accumulation and response to adjuvant chemotherapy in premenopausal women with node-negative early breast cancer. Clahsen, P.C., van de Velde, C.J., Duval, C., Pallud, C., Mandard, A.M., Delobelle-Deroide, A., van den Broek, L., Sahmoud, T.M., van de Vijver, M.J. J. Clin. Oncol. (1998)
- Breast cancer risk in usual ductal hyperplasia is defined by estrogen receptor-alpha and Ki-67 expression. Shaaban, A.M., Sloane, J.P., West, C.R., Foster, C.S. Am. J. Pathol. (2002)
- P53 expression in breast cancer. Cattoretti, G., Rilke, F., Andreola, S., D'Amato, L., Delia, D. Int. J. Cancer (1988)
- Ki-67 staining in benign, borderline, malignant primary and metastatic ovarian tumors: correlation with steroid receptors, epidermal-growth-factor receptor and cathepsin D. Henzen-Logmans, S.C., Fieret, E.J., Berns, E.M., van der Burg, M.E., Klijn, J.G., Foekens, J.A. Int. J. Cancer (1994)
- Valosin-containing protein (p97) and Ki-67 expression is a useful marker in detecting malignant behavior of pancreatic endocrine neoplasms. Yamamoto, S., Tomita, Y., Nakamori, S., Hoshida, Y., Iizuka, N., Okami, J., Nagano, H., Dono, K., Umeshita, K., Sakon, M., Ishikawa, O., Ohigashi, H., Aozasa, K., Monden, M. Oncology (2004)
- Clinical decision making in Barrett's oesophagus can be supported by computerized immunoquantitation and morphometry of features associated with proliferation and differentiation. Polkowski, W., Baak, J.P., van Lanschot, J.J., Meijer, G.A., Schuurmans, L.T., Ten Kate, F.J., Obertop, H., Offerhaus, G.J. J. Pathol. (1998)
- Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions. Nagy, Z., Esiri, M.M., Smith, A.D. Acta Neuropathol. (1997)
- Apoptosis-related proteins and cervical intraepithelial neoplasia in human immunodeficiency virus-seropositive women. Spinillo, A., Zara, F., Zappatore, R., Cesari, S., Bergante, C., Morbini, P. Gynecol. Oncol. (2004)
- IL-2-induced CD4+ T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation. Sereti, I., Anthony, K.B., Martinez-Wilson, H., Lempicki, R., Adelsberger, J., Metcalf, J.A., Hallahan, C.W., Follmann, D., Davey, R.T., Kovacs, J.A., Lane, H.C. Blood (2004)
- Evidence that human cardiac myocytes divide after myocardial infarction. Beltrami, A.P., Urbanek, K., Kajstura, J., Yan, S.M., Finato, N., Bussani, R., Nadal-Ginard, B., Silvestri, F., Leri, A., Beltrami, C.A., Anversa, P. N. Engl. J. Med. (2001)
- The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review on 5232 patients. Klijn, J.G., Berns, P.M., Schmitz, P.I., Foekens, J.A. Endocr. Rev. (1992)
- Turnover of CD4+ and CD8+ T lymphocytes in HIV-1 infection as measured by Ki-67 antigen. Sachsenberg, N., Perelson, A.S., Yerly, S., Schockmel, G.A., Leduc, D., Hirschel, B., Perrin, L. J. Exp. Med. (1998)
- Comparison of estrogen and progesterone receptor, Ki-67, and p53 immunoreactivity in uterine endometrioid carcinoma and endometrioid carcinoma with squamous, mucinous, secretory, and ciliated cell differentiation. Lax, S.F., Pizer, E.S., Ronnett, B.M., Kurman, R.J. Hum. Pathol. (1998)
- A significance of immunohistochemical determination of steroid receptors, cell proliferation factor Ki-67 and protein p53 in endometrial carcinoma. Oreskovic, S., Babic, D., Kalafatic, D., Barisic, D., Beketic-Oreskovic, L. Gynecol. Oncol. (2004)
- Estimation of tumor growth fractions in archival formalin-fixed, paraffin-embedded tissues using two anti-PCNA/Cyclin monoclonal antibodies. Factors affecting reactivity. Gelb, A.B., Kamel, O.W., LeBrun, D.P., Warnke, R.A. Am. J. Pathol. (1992)
- Immunohistochemical detection of progesterone receptors and the correlation with Ki-67 labeling indices in paraffin-embedded sections of meningiomas. Nagashima, G., Aoyagi, M., Wakimoto, H., Tamaki, M., Ohno, K., Hirakawa, K. Neurosurgery (1995)
- Effects of daily low dose mifepristone on endometrial maturation and proliferation. Cameron, S.T., Critchley, H.O., Thong, K.J., Buckley, C.H., Williams, A.R., Baird, D.T. Hum. Reprod. (1996)
- AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling. Riemenschneider, M.J., Betensky, R.A., Pasedag, S.M., Louis, D.N. Cancer Res. (2006)
- A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis. Takagi, M., Sueishi, M., Saiwaki, T., Kametaka, A., Yoneda, Y. J. Biol. Chem. (2001)
- High expression of the trefoil protein TFF1 in interval breast cancers. Crosier, M., Scott, D., Wilson, R.G., Griffiths, C.D., May, F.E., Westley, B.R. Am. J. Pathol. (2001)
- Phase II clinical trial of N-(4-Hydroxyphenyl)retinamide and tamoxifen administration before definitive surgery for breast neoplasia. Singletary, S.E., Atkinson, E.N., Hoque, A., Sneige, N., Sahin, A.A., Fritsche, H.A., Lotan, R., Lu, T., Hittelman, W.N., Bevers, T.B., Stelling, C.B., Lippman, S.M. Clin. Cancer Res. (2002)
- Prediction of response to neoadjuvant chemoendocrine therapy in primary breast carcinomas. Makris, A., Powles, T.J., Dowsett, M., Osborne, C.K., Trott, P.A., Fernando, I.N., Ashley, S.E., Ormerod, M.G., Titley, J.C., Gregory, R.K., Allred, D.C. Clin. Cancer Res. (1997)
- Effects of mifepristone on proliferation and apoptosis of human endometrium in new users of medroxyprogesterone acetate. Jain, J.K., Li, A., Yang, W., Minoo, P., Felix, J.C. Hum. Reprod. (2006)
- Detection of mutations in the cDNA of the proliferation marker Ki-67 protein in four tumor cell lines. Bubán, T., Schmidt, M., Broll, R., Antal-Szalmás, P., Duchrow, M. Cancer Genet. Cytogenet. (2004)
- Expression of the cyclin kinase inhibitor, p27kip1, in developing and mature human kidney. Combs, H.L., Shankland, S.J., Setzer, S.V., Hudkins, K.L., Alpers, C.E. Kidney Int. (1998)
- Endocrine tumors of the pancreas: Ki-67 immunoreactivity on paraffin sections is an independent predictor for malignancy: a comparative study with proliferating-cell nuclear antigen and progesterone receptor protein immunostaining, mitotic index, and other clinicopathologic variables. Pelosi, G., Bresaola, E., Bogina, G., Pasini, F., Rodella, S., Castelli, P., Iacono, C., Serio, G., Zamboni, G. Hum. Pathol. (1996)
- Letrozole inhibits tumor proliferation more effectively than tamoxifen independent of HER1/2 expression status. Ellis, M.J., Coop, A., Singh, B., Tao, Y., Llombart-Cussac, A., Jänicke, F., Mauriac, L., Quebe-Fehling, E., Chaudri-Ross, H.A., Evans, D.B., Miller, W.R. Cancer Res. (2003)
- Effects of soy-protein supplementation on epithelial proliferation in the histologically normal human breast. McMichael-Phillips, D.F., Harding, C., Morton, M., Roberts, S.A., Howell, A., Potten, C.S., Bundred, N.J. Am. J. Clin. Nutr. (1998)
- Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase. Becker, K.A., Ghule, P.N., Therrien, J.A., Lian, J.B., Stein, J.L., van Wijnen, A.J., Stein, G.S. J. Cell. Physiol. (2006)
- Dissociation between steroid receptor expression and cell proliferation in the human breast. Clarke, R.B., Howell, A., Potten, C.S., Anderson, E. Cancer Res. (1997)
- Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions. Li, H., Byeon, I.J., Ju, Y., Tsai, M.D. J. Mol. Biol. (2004)
- The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure. Scholzen, T., Endl, E., Wohlenberg, C., van der Sar, S., Cowell, I.G., Gerdes, J., Singh, P.B. J. Pathol. (2002)
- Galanin and galanin receptors in human gliomas. Berger, A., Santic, R., Almer, D., Hauser-Kronberger, C., Huemer, M., Humpel, C., Stockhammer, G., Sperl, W., Kofler, B. Acta Neuropathol. (2003)
- Both estrogen receptor alpha and estrogen receptor beta agonists enhance cell proliferation in the dentate gyrus of adult female rats. Mazzucco, C.A., Lieblich, S.E., Bingham, B.I., Williamson, M.A., Viau, V., Galea, L.A. Neuroscience (2006)
- p16 is a robust in vivo biomarker of cellular aging in human skin. Ressler, S., Bartkova, J., Niederegger, H., Bartek, J., Scharffetter-Kochanek, K., Jansen-Dürr, P., Wlaschek, M. Aging Cell (2006)
- PCNA/cyclin expression and BrdU uptake define different subpopulations in different cell lines. Coltrera, M.D., Gown, A.M. J. Histochem. Cytochem. (1991)
- Topological analysis of p21WAF1/CIP1 expression in esophageal squamous dysplasia. Shirakawa, Y., Naomoto, Y., Kimura, M., Kawashima, R., Yamatsuji, T., Tamaki, T., Hamada, M., Haisa, M., Tanaka, N. Clin. Cancer Res. (2000)
- Overexpression of human telomerase RNA is an early event in oesophageal carcinogenesis. Hiyama, T., Yokozaki, H., Kitadai, Y., Haruma, K., Yasui, W., Kajiyama, G., Tahara, E. Virchows Arch. (1999)
- Estrogen receptor beta in breast cancer: associations between ERbeta, hormonal receptors, and other prognostic biomarkers. Choi, Y., Pinto, M. Appl. Immunohistochem. Mol. Morphol. (2005)
- Neoadjuvant percutaneous 4-hydroxytamoxifen decreases breast tumoral cell proliferation: a prospective controlled randomized study comparing three doses of 4-hydroxytamoxifen gel to oral tamoxifen. Rouanet, P., Linares-Cruz, G., Dravet, F., Poujol, S., Gourgou, S., Simony-Lafontaine, J., Grenier, J., Kramar, A., Girault, J., Le Nestour, E., Maudelonde, T. J. Clin. Oncol. (2005)
- Biologic markers as predictors of clinical outcome from systemic therapy for primary operable breast cancer. Chang, J., Powles, T.J., Allred, D.C., Ashley, S.E., Clark, G.M., Makris, A., Assersohn, L., Gregory, R.K., Osborne, C.K., Dowsett, M. J. Clin. Oncol. (1999)
- Prediction of clinical outcome from primary tamoxifen by expression of biologic markers in breast cancer patients. Chang, J., Powles, T.J., Allred, D.C., Ashley, S.E., Makris, A., Gregory, R.K., Osborne, C.K., Dowsett, M. Clin. Cancer Res. (2000)
- Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas. Girault, I., Tozlu, S., Lidereau, R., Bièche, I. Clin. Cancer Res. (2003)
- Relationship between E-cadherin gene mutation and p53 gene mutation, p53 accumulation, Bcl-2 expression and Ki-67 staining in diffuse-type gastric carcinoma. Fricke, E., Keller, G., Becker, I., Rosivatz, E., Schott, C., Plaschke, S., Rudelius, M., Hermannstädter, C., Busch, R., Höfler, H., Becker, K.F., Luber, B. Int. J. Cancer (2003)
- Amplification of erbB2 and erbB2 expression are superior to estrogen receptor status as risk factors for distant recurrence in pT1N0M0 breast cancer: a nationwide population-based study. Joensuu, H., Isola, J., Lundin, M., Salminen, T., Holli, K., Kataja, V., Pylkkänen, L., Turpeenniemi-Hujanen, T., von Smitten, K., Lundin, J. Clin. Cancer Res. (2003)
- Apocrine ductal carcinoma in situ of the breast: histologic classification and expression of biologic markers. Leal, C., Henrique, R., Monteiro, P., Lopes, C., Bento, M.J., De Sousa, C.P., Lopes, P., Olson, S., Silva, M.D., Page, D.L. Hum. Pathol. (2001)
- Expression of p53 gene product and cell proliferation marker Ki-67 in Ewing's sarcoma: correlation with clinical outcome. Amir, G., Issakov, J., Meller, I., Sucher, E., Peyser, A., Cohen, I.J., Yaniv, I., Ben Arush, M.W., Tavori, U., Kollender, Y., Ron, N., Peylan-Ramu, N. Hum. Pathol. (2002)