Disease relevance of TNFSF14

• LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis [1].
• Constitutive expression and costimulatory function of LIGHT/TNFSF14 on human melanoma cells and melanoma-derived microvesicles [2].
• Lack of efficacy of light reduction in preventing retinopathy of prematurity. Light Reduction in Retinopathy of Prematurity (LIGHT-ROP) Cooperative Group [3].
• Letter: Light on Psoriasis [4].
• Amiodarone-associated phospholipidosis and fibrosis of the liver. Light, immunohistochemical, and electron microscopic studies [5].

Psychiatry related information on TNFSF14

• CONCLUSIONS: Light-to-moderate alcohol consumption reduced the overall risk of stroke and the risk of ischemic stroke in men [6].
• CONCLUSIONS: Light-responsive seasonal affective disorder is distinguished by a dominant atypical symptom profile closely associated with depressed mood [7].
• Four treatments during a 45.5 h sleep deprivation period were compared: Dim Light-Placebo, Dim Light-Caffeine, Bright Light-Placebo and Bright-Light Caffeine [8].
• During each 10-sec epoch of Active Sleep a rating was made of the infant's rapid eye movements, as follows: No REM, Light REMs, Moderate REMs, or intense REMs (REM Storms) [9].
• OBJECTIVE: To evaluate systematically the effectiveness of six advertising strategies (two message strategies presented in three different contexts) designed to promote smoking cessation by addressing smokers' misperceptions about Light cigarettes [10].

High impact information on TNFSF14

• Consistently, enhancing LTbetaR signaling by transgenic expression of TNFSF14 in the islets of NOD mice rapidly promoted de novo formation of local TLO, resulting in diabetes, even in the absence of draining lymph nodes (LN) [11].
• LIGHT, a newly discovered TNF superfamily member (TNFSF14), is expressed on activated T cells and immature dendritic cells [12].
• Colon epithelium. I. Light microscopic, histochemical, and ultrastructural features of normal colon epithelium of male Fischer 344 rats [13].
• Results: Light microscopy demonstrated pale pink, oval to crescentic intracytoplasmic inclusions with a predilection for periportal hepatocytes but sometimes present throughout the lobules [14].
• BACKGROUND & AIMS: Light dosimetry analysis to achieve predictable tumor necrosis has not been performed for photodynamic therapy (PDT) in the gastrointestinal tract [15].

Chemical compound and disease context of TNFSF14

• The Can-SAD Study: A Randomized Controlled Trial of the Effectiveness of Light Therapy and Fluoxetine in Patients With Winter Seasonal Affective Disorder [16].
• False-Positive Result from a Bayer Versant Human Immunodeficiency Virus Type 1 Branched-DNA Viral Load Assay, with a Possible Role for Light Leakage after Inadequate Maintenance of the Analyzer [17].
• The chelation capability of the reactive dye Light Resistant Yellow 2KT towards metal ions, particularly mercury(II) was evaluated in the pH range 5.0-7.0, and it was shown that the dye-Hg(II) complex has a free site for the interaction with human recombinant granulocyte-colony stimulating factor (rhG-CSF) from Escherichia coli [18].
• Ichthyosis hystrix (Curth-Macklin). Light and electron microscopic studies performed before and after etretinate treatment [19].
• Topical 5-Aminolevulinic Acid Mediated Photodynamic Therapy of Superficial Basal Cell Carcinoma Using Two Light Fractions with a Two-hour Interval: Long-term Follow-up [20].

Biological context of TNFSF14

• TNFSF14 induces apoptosis and suppresses tumor formation [21].
• The deduced amino acid sequence of the mouse TNFSF14 (mTNFSF14) cDNA comprised 239 amino acid residues and was 77% identical to the hTNFSF14 protein [21].
• TNFSF14/LIGHT is a member of the tumor necrosis factor superfamily that binds to lymphotoxin-beta receptor (LTbetaR) to induce cell death via caspase-dependent and caspase-independent pathways [22].
• DISCUSSION: Light reaching the eyes via the snow or other reflecting involved in certain biological phenomena that exhibit seasonal variations such as reproductive and self-destructive behaviours [23].
• Nuclear-mediated mitochondrial gene regulation and male fertility in higher plants: Light at the end of the tunnel [24]?

Anatomical context of TNFSF14

• However, in this study, we show that human melanoma cells express LIGHT/TNFSF14, a ligand of herpesvirus entry mediator on T cells and of lymphotoxin beta receptor on stromal cells [2].
• HVEM-L mRNA is expressed in spleen, lymph nodes, macrophages, and T cells and encodes a 240-amino acid protein [25].
• Our data suggest that TR6 inhibits the interactions of LIGHT with HVEM/TR2 and LTbetaR, thereby suppressing LIGHT- mediated HT29 cell death [26].
• LIGHT (TNFSF14), a member of the tumor necrosis factor (TNF) superfamily, efficiently activates both T cells and antigen-presenting cells (APCs) [27].
• METHODS: Light microscopic examination of subserial sections of the sinus node, atrioventricular node and His bundle, coronary chemoreceptor and regional nerves, ganglia, and small coronary arteries [28].

Associations of TNFSF14 with chemical compounds

• The effects of monensin on transport of membrane components in the frog retinal photoreceptor. I. Light microscopic autoradiography and biochemical analysis [29].
• The Exchange Factor and Diacylglycerol Receptor RasGRP3 Interacts with Dynein Light Chain 1 through Its C-terminal Domain [30].
• This synergy arises because Ras-GTP translocates Raf-1 to the plasma membrane where it becomes phosphorylated on tyrosine residues 340 and 341 by membrane-bound tyrosine kinases (Marais, R., Light, Y., Paterson, H. F., and Marshall, C. J. (1995) EMBO J. 14, 3136-3145) [31].
• CONCLUSIONS: Light treatment showed earlier response onset and lower rate of some adverse events relative to fluoxetine, but there were no other significant differences in outcome between light therapy and antidepressant medication [16].
• PAS Domain Allostery and Light-induced Conformational Changes in Photoactive Yellow Protein upon I(2) Intermediate Formation, Probed with Enhanced Hydrogen/Deuterium Exchange Mass Spectrometry [32].

Regulatory relationships of TNFSF14

• Light-regulated biochemical events in invertebrate photoreceptors. 2. Light-regulated phosphorylation of rhodopsin and phosphoinositides in squid photoreceptor membranes [33].

Other interactions of TNFSF14

• Molecular cloning and characterization of a mouse homolog of human TNFSF14, a member of the TNF superfamily [21].
• Sustained expression of lymphotoxin-like inducible protein that competes with glycoprotein D for binding herpesvirus entry mediator on T cells (LIGHT) (TNFSF14) causes a pathological intestinal inflammation when constitutively expressed by mouse T cells [34].
• Activation of the Fanconi Anemia/BRCA Pathway and Recombination Repair in the Cellular Response to Solar Ultraviolet Light [35].
• CONCLUSION: Light-to-moderate alcohol intake is associated with a lower prevalence of vascular brain findings and, in APOE epsilon4 carriers, hippocampal and amygdalar atrophy on MRI [36].
• NAT2*5A, NAT2*6A, NAT2*7A/B, and NAT2*14A were detected by use of LightCycler-NAT2 mutation detection kit by real-time polymerase chain reaction with Light Cycler instruments [37].

Analytical, diagnostic and therapeutic context of TNFSF14

• METHODS AND RESULTS: Light and transmission electron microscopy demonstrated typical features of apoptosis in human umbilical vein endothelial cells (HUVEC) exposed to tumor necrosis factor-alpha (TNF-alpha) [38].
• "Occlusion angioplasty". Light at the end of the tunnel or dead end [39]?
• The presence and possible role of monocyte infiltration in human chronic proliferative glomerulonephritides. Light microscopic, immunofluorescence, and histochemical correlations [40].
• Only one EV locus was detected in the unrelated Light Brown Leghorn control chickens (1q14) by in situ hybridization, whereas 3 EV loci were identified in SL101 and BL101 chickens (1p25, 2q26, and an unidentifiable microchromosome) [41].
• Pulmonary morphology in a multihospital collaborative extracorporeal membrane oxygenation project. I. Light microscopy [42].

References